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PKM [extracellular region]
Stable Identifier
R-HSA-6806491
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Pyruvate kinase PKM ecNumber2.7.1.40/ecNumber, KPYM_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
PKM [extracellular region] (Homo sapiens)
Exocytosis of secretory granule lumen proteins (Homo sapiens)
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
PKM [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14618 PKM
Gene Names
PKM, OIP3, PK2, PK3, PKM2
Chain
initiator methionine:1, chain:2-531
Reference Genes
BioGPS Gene:5315 PKM
COSMIC (genes):PKM PKM
CTD Gene:5315 PKM
dbSNP Gene:5315 PKM
ENSEMBL:ENSG00000067225 PKM
HGNC:9021 PKM
KEGG Gene (Homo sapiens):5315 PKM
Monarch:5315 PKM
NCBI Gene:5315 PKM
OMIM:179050 PKM
UCSC:P14618 PKM
Reference Transcript
RefSeq:NM_182471.3 PKM
RefSeq:NM_182470.3 PKM
RefSeq:XM_017022313.1 PKM
RefSeq:XM_005254445.4 PKM
RefSeq:NM_001316318.1 PKM
RefSeq:NM_002654.5 PKM
RefSeq:NM_001206799.1 PKM
RefSeq:NM_001206797.2 PKM
RefSeq:NM_001206796.2 PKM
RefSeq:NM_001206798.2 PKM
Other Identifiers
0002030537
0006200152
0006510452
11722787_a_at
11752165_s_at
11752166_x_at
11752342_x_at
11752458_a_at
11756971_x_at
16811372
201251_at
2893336
2893342
3103883
3103886
3103891
3103895
32378_at
3631965
3631966
3631967
3631968
3631969
3631971
3631977
3631984
3631989
3631992
3631993
3631998
3631999
3632000
3632003
3632005
3632007
3632010
3632011
3632015
3632029
3632030
3632031
3632032
3632033
3632034
3632035
3632036
3979839
5315
7990151
A_23_P399501
A_32_P147241
GE81173
GO:0000166
GO:0000287
GO:0001666
GO:0001889
GO:0002376
GO:0003674
GO:0003723
GO:0003729
GO:0003824
GO:0004743
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005739
GO:0005783
GO:0005791
GO:0005829
GO:0005929
GO:0005975
GO:0006006
GO:0006091
GO:0006096
GO:0006412
GO:0006417
GO:0006754
GO:0006810
GO:0006950
GO:0007584
GO:0008150
GO:0008152
GO:0008219
GO:0009056
GO:0009058
GO:0009629
GO:0010033
GO:0012501
GO:0014870
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0023026
GO:0030955
GO:0031012
GO:0031100
GO:0031410
GO:0031982
GO:0032868
GO:0032869
GO:0032991
GO:0034641
GO:0034774
GO:0040007
GO:0042802
GO:0042866
GO:0043167
GO:0043226
GO:0043312
GO:0043403
GO:0043531
GO:0044281
GO:0045296
GO:0046872
GO:0048646
GO:0048856
GO:0061621
GO:0062023
GO:0070062
GO:0070324
GO:1902912
GO:1903561
GO:1903672
GO:1904813
GO:2000767
HMNXSV003020043
ILMN_1663122
ILMN_1672650
ILMN_1775327
ILMN_2366634
PH_hs_0029415
TC15002609.hg
TC15002610.hg
TC15002776.hg
X56494_at
g4505838_3p_at
g4505838_3p_x_at
Participates
as a member of
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
PKM [ficolin-1-rich granule lumen]
PKM [secretory granule lumen]
Inferred To
pklr [extracellular region]
(Danio rerio)
CDC19 [extracellular region]
(Saccharomyces cerevisiae)
pkma [extracellular region]
(Danio rerio)
pkmb [extracellular region]
(Danio rerio)
PYK2 [extracellular region]
(Saccharomyces cerevisiae)
pyk-1 [extracellular region]
(Caenorhabditis elegans)
Dmel\CG2964 [extracellular region]
(Drosophila melanogaster)
pyk1 [extracellular region]
(Schizosaccharomyces pombe)
Dmel\CG12229 [extracellular region]
(Drosophila melanogaster)
pyk-2 [extracellular region]
(Caenorhabditis elegans)
Dmel\CG7069 [extracellular region]
(Drosophila melanogaster)
LOC100362738 [extracellular region]
(Rattus norvegicus)
pyk [extracellular region]
(Dictyostelium discoideum)
Dmel\CG7362 [extracellular region]
(Drosophila melanogaster)
Homologues of PKM [extracellular region]
(Caenorhabditis elegans)
Homologues of PKM [extracellular region]
(Danio rerio)
Homologues of PKM [extracellular region]
(Drosophila melanogaster)
Homologues of PKM [extracellular region]
(Plasmodium falciparum)
Homologues of PKM [extracellular region]
(Saccharomyces cerevisiae)
PKM [extracellular region]
(Bos taurus)
PKM [extracellular region]
(Gallus gallus)
PKM [extracellular region]
(Plasmodium falciparum)
PKM [extracellular region]
(Sus scrofa)
Dmel\CG11249 [extracellular region]
(Drosophila melanogaster)
PyK [extracellular region]
(Drosophila melanogaster)
Pkm [extracellular region]
(Mus musculus)
Cross References
RefSeq
NP_001303247.1
,
NP_001193725.1
,
NP_001193727.1
,
NP_872270.1
,
NP_002645.3
,
NP_872271.1
,
NP_001193728.1
,
XP_005254502.1
,
NP_001193726.1
,
XP_016877802.1
OpenTargets
ENSG00000067225
ZINC - Substances
KPYM_HUMAN
ZINC target
P14618
ZINC - Biogenic
KPYM_HUMAN
PRO
P14618
PDB
6WP4
,
6NU5
,
5X0I
,
1T5A
,
4JPG
,
6B6U
,
4WJ8
,
3U2Z
,
4QGC
,
3H6O
,
3SRH
,
3G2G
,
6WP5
,
4FXJ
,
6GG3
,
4QG8
,
6JFB
,
6GG6
,
1ZJH
,
6TTI
,
5X1W
,
6V76
,
3GR4
,
3BJF
,
4YJ5
,
6NU1
,
6V74
,
6TTQ
,
6WP3
,
4QG9
,
3SRF
,
6NUB
,
3GQY
,
6TTF
,
6GG4
,
4G1N
,
6TTH
,
3BJT
,
6V75
,
4QG6
,
4FXF
,
4B2D
,
5X1V
,
3SRD
,
4RPP
,
6WP6
,
3ME3
,
6GG5
Target Pathogen
5b354852be737e166372e75f
ZINC - Metabolites
KPYM_HUMAN
GeneCards
P14618
HPA
ENSG00000067225-PKM
Ensembl
ENST00000568459
,
ENSP00000455901
,
ENSP00000334983
,
ENST00000335181
,
ENSG00000067225
,
ENST00000565184
,
ENSP00000456970
,
ENSP00000320171
,
ENST00000319622
,
ENST00000565154
,
ENSP00000455736
ZINC - Predictions - Purchasable
KPYM_HUMAN
HMDB Protein
HMDBP00763
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
9
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P35222 CTNNB1
33
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
Ub-K,p-Y-CTNNB1 [cytosol]
(R-HSA-8877006)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
0.524
4
UniProt:P32121 ARRB2
2
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [cytosol]
(R-HSA-416464)
0.499
4
UniProt:P49407 ARRB1
5
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [cytosol]
(R-HSA-264470)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.499
3
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