Reactome | PSMA2 [extracellular region]

PSMA2 [extracellular region]

Stable Identifier

R-HSA-6806506

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Proteasome subunit alpha type 2 , Proteasome component C3, Macropain subunit C3, Multicatalytic endopeptidase complex subunit C3

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P25787 PSMA2

Gene Names

PSMA2, HC3, PSC3

Chain

initiator methionine:, chain:2-234

Reference Genes

BioGPS Gene:5683 PSMA2

COSMIC (genes):PSMA2 PSMA2

CTD Gene:5683 PSMA2

dbSNP Gene:5683 PSMA2

ENSEMBL:ENSG00000106588 PSMA2

HGNC:9531 PSMA2

KEGG:hsa:5683 PSMA2

Monarch:5683 PSMA2

NCBI Gene:5683 PSMA2

OMIM:176842 PSMA2

UCSC:P25787 PSMA2

Reference Transcript

RefSeq:NM_002787.4 PSMA2

Other Identifiers

11719275_a_at

11757361_x_at

1446_at

17057035

201316_PM_at

201316_at

201317_PM_s_at

201317_s_at

2523133

3047965

3047966

3047967

3047968

3047969

3047970

3047971

3047972

3047973

3047974

3047975

3047976

3047977

3047978

3047979

3047980

3047983

3047984

3047987

3047988

3047989

41240_at

5683

8139232

A_23_P345591

D00760_at

GE79408

GO:0000502

GO:0000932

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0006511

GO:0009615

GO:0019773

GO:0030163

GO:0034774

GO:0043161

GO:0043226

GO:0051603

GO:0070062

GO:1904813

HMNXSV003010728

Hs.181309.0.S2_3p_at

ILMN_2058512

PH_hs_0023846

PH_hs_0035799

TC07003353.hg

g4506180_3p_a_at

Participates

as a member of

Other forms of this molecule

PSMA2 [cytosol]

PSMA2 [nucleoplasm]

PSMA2 [secretory granule lumen]

PSMA2 [ficolin-1-rich granule lumen]

Inferred To

Prosalpha2 [extracellular region] (Drosophila melanogaster)

psmA2 [extracellular region] (Dictyostelium discoideum)

psma2b [extracellular region] (Danio rerio)

psma2 [extracellular region] (Xenopus tropicalis)

psma2a [extracellular region] (Danio rerio)

PRE8 [extracellular region] (Saccharomyces cerevisiae)

pre8 [extracellular region] (Schizosaccharomyces pombe)

Psma2 [extracellular region] (Mus musculus)

Psma2 [extracellular region] (Rattus norvegicus)

Homologues of PSMA2 [extracellular region] (Danio rerio)

PSMA2 [extracellular region] (Bos taurus)

PSMA2 [extracellular region] (Canis familiaris)

PSMA2 [extracellular region] (Gallus gallus)

PSMA2 [extracellular region] (Plasmodium falciparum)

PSMA2 [extracellular region] (Sus scrofa)

pas-2 [extracellular region] (Caenorhabditis elegans)

Cross References

RefSeq

NP_002778.1

OpenTargets

ENSG00000106588

ENSEMBL

ENST00000223321, ENSP00000223321

HPA

ENSG00000106588-PSMA2

PRO

P25787

Pharos - Targets

P25787

GlyGen

P25787

PDB

7AWE, 6R70, 5LF4, 5LF7, 5LF6, 5LEX, 7NAQ, 6WJD, 8QYM, 7W37, 8QYL, 7NAO, 8QYO, 7W3J, 7W3A, 7W3G, 6MSH, 5VFT, 5LF0, 7NAP, 8UD9, 5VFQ, 6RGQ, 7QXU, 6XMJ, 5GJR, 5VFP, 7NHT, 6MSD, 5A0Q, 8QZ9, 7W3C, 8QYS, 7QXP, 7QY7, 7QXX, 5T0J, 5LE5, 5T0G, 5M32, 4R3O, 6REY, 8CVT, 8BZL, 7QYB, 8CVS, 8CXB, 6E5B, 7LXV, 5LF3, 4R67, 5LEZ, 7W38, 5LEY, 7W3B, 6MSB, 6MSJ, 6MSK, 5LF1, 7V5M, 6WJN, 7NAN, 6KWY, 5VFS, 7W39, 8QYN, 7W3H, 7W3I, 5VFU, 6MSG, 5VFR, 7B12, 5VFO, 7QXW, 6AVO, 8QYJ, 7W3F, 7QXN, 7W3K, 7W3M, 6MSE, 7V5G, 5GJQ, 5LN3, 5T0I, 5T0C, 5T0H, 7PG9, 8CVR, 7QYA, 5L4G

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.952	21
UniProt:P25789 PSMA4	2	PSMA4 [cytosol] (R-HSA-68730) PSMA4 [nucleoplasm] (R-HSA-174324)	0.908	12
UniProt:O14818 PSMA7	2	PSMA7 [nucleoplasm] (R-HSA-174351) PSMA7 [cytosol] (R-HSA-68736)	0.85	9
UniProt:P60900 PSMA6	2	PSMA6 [cytosol] (R-HSA-68734) PSMA6 [nucleoplasm] (R-HSA-174314)	0.845	10
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.837	9
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129)	0.788	8
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143)	0.788	9
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.788	9
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.788	8
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.738	6
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.728	4
UniProt:P28066 PSMA5	5	PSMA5 [cytosol] (R-HSA-68732) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [secretory granule lumen] (R-HSA-6803316) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328)	0.725	9
UniProt:P28072 PSMB6	4	PSMB6 [cytosol] (R-HSA-68756) PSMB6 [nucleoplasm] (R-HSA-174342) pro-PSMB6 [cytosol] (R-HSA-9908130) PSMB6(1-34) [cytosol] (R-HSA-9908141)	0.725	7
UniProt:P28074 PSMB5	4	PSMB5 [cytosol] (R-HSA-68753) PSMB5 [nucleoplasm] (R-HSA-174344) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5(1-59) [cytosol] (R-HSA-9908134)	0.725	6
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.643	6
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.643	4
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440)	0.564	3
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.564	2
UniProt:Q9UL46 PSME2	2	PSME2 [nucleoplasm] (R-HSA-174350) PSME2 [cytosol] (R-HSA-68814)	0.527	4
UniProt:P25786-2 PSMA1			0.527	3
UniProt:O43242 PSMD3	5	PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408)	0.527	3
UniProt:P40306 PSMB10	3	pro-PSMB10 [cytosol] (R-HSA-9908123) PSMB10 [cytosol] (R-HSA-68741) PSMB10(1-39) [cytosol] (R-HSA-9908142)	0.527	2
UniProt:Q14997 PSME4	1	PSME4 [cytosol] (R-HSA-947606)	0.527	5
UniProt:Q5JS54 PSMG4	1	PSMG4 [cytosol] (R-HSA-9908036)	0.527	4
UniProt:O95456 PSMG1	1	PSMG1 [cytosol] (R-HSA-9908050)	0.527	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	5
UniProt:Q99460 PSMD1	4	PSMD1 [extracellular region] (R-HSA-6806194) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [cytosol] (R-HSA-68786)	0.527	2
UniProt:Q9BT73 PSMG3	1	PSMG3 [cytosol] (R-HSA-9908033)	0.527	4
UniProt:Q92530 PSMF1	1	PSMF1 [cytosol] (R-HSA-68818)	0.527	4
UniProt:Q969U7 PSMG2	1	PSMG2 [cytosol] (R-HSA-9908053)	0.527	4
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429)	0.527	2
UniProt:Q06323 PSME1	1	PSME1 [cytosol] (R-HSA-68812)	0.527	4
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436)	0.527	2
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416)	0.527	2
UniProt:Q6S8E0 Q6S8E0			0.508	2
UniProt:Q6VN20 RANBP10	1	RANBP10 [cytosol] (R-HSA-8851865)	0.508	2

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