Reactome | DDX3X [extracellular region]

DDX3X [extracellular region]

Stable Identifier

R-HSA-6806507

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

ATP-dependent RNA helicase DDX3X ecNumber3.6.4.13/ecNumber, DDX3X_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O00571 DDX3X

Gene Names

DDX3X, DBX, DDX3

Chain

initiator methionine:1, chain:2-662

Reference Genes

BioGPS Gene:1654 DDX3X

COSMIC (genes):DDX3X DDX3X

CTD Gene:1654 DDX3X

dbSNP Gene:1654 DDX3X

ENSEMBL:ENSG00000215301 DDX3X

HGNC:2745 DDX3X

KEGG Gene (Homo sapiens):1654 DDX3X

Monarch:1654 DDX3X

NCBI Gene:1654 DDX3X

OMIM:300160 DDX3X

UCSC:O00571 DDX3X

Reference Transcript

Other Identifiers

0003450440

0003450487

0005420176

11715903_at

11715904_s_at

11715905_x_at

11748960_a_at

11750750_a_at

11750751_x_at

11752296_x_at

11758021_s_at

1654

17102755

201210_PM_at

201210_at

201211_PM_s_at

201211_s_at

207617_PM_at

207617_at

212514_3p_x_at

212514_PM_x_at

212514_x_at

212515_PM_s_at

212515_s_at

39744_at

3974845

3974846

3974847

3974848

3974851

3974854

3974856

3974857

3974859

3974861

3974863

3974865

3974866

3974867

3974868

3974870

3974872

3974875

3974876

3974877

3974879

3974880

3974881

3974882

3974883

3974884

3974885

3974886

3974887

3974889

3974891

3974892

4030183

8166876

826_at

87502_at

A_14_P111515

A_23_P125656

A_23_P317654

A_24_P126060

GE54028

GE81012

GO:0000003

GO:0000166

GO:0000278

GO:0002376

GO:0003674

GO:0003676

GO:0003677

GO:0003678

GO:0003723

GO:0003724

GO:0003729

GO:0003924

GO:0004386

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005840

GO:0005852

GO:0005856

GO:0005886

GO:0006412

GO:0006413

GO:0006417

GO:0006464

GO:0006915

GO:0006950

GO:0007049

GO:0007059

GO:0007165

GO:0007267

GO:0007276

GO:0008092

GO:0008134

GO:0008143

GO:0008150

GO:0008190

GO:0008219

GO:0008625

GO:0009058

GO:0009615

GO:0010494

GO:0010501

GO:0010628

GO:0016020

GO:0016055

GO:0016787

GO:0016887

GO:0017111

GO:0017148

GO:0022607

GO:0022627

GO:0030027

GO:0030154

GO:0030234

GO:0030307

GO:0030308

GO:0031053

GO:0031252

GO:0031333

GO:0031369

GO:0031410

GO:0031954

GO:0032508

GO:0032727

GO:0032728

GO:0032991

GO:0033592

GO:0034063

GO:0034157

GO:0034161

GO:0034641

GO:0034774

GO:0035556

GO:0035613

GO:0036493

GO:0040007

GO:0042254

GO:0042256

GO:0042592

GO:0042995

GO:0043015

GO:0043024

GO:0043065

GO:0043066

GO:0043154

GO:0043167

GO:0043186

GO:0043226

GO:0043273

GO:0043280

GO:0043539

GO:0045070

GO:0045087

GO:0045296

GO:0045727

GO:0045944

GO:0045948

GO:0048027

GO:0051276

GO:0055088

GO:0061702

GO:0065003

GO:0070062

GO:0071243

GO:0071470

GO:0071651

GO:0071902

GO:0072559

GO:0090263

GO:0097193

GO:0098586

GO:0140657

GO:1900087

GO:1900227

GO:1901223

GO:1901224

GO:1901985

GO:1902042

GO:1902523

GO:1903608

GO:1904813

GO:2001243

HMNXSV003025979

HMNXSV003028541

HMNXSV003034886

Hs.147916.2.A1_3p_a_at

Hs.147916.2.A1_3p_s_at

Hs.147916.2.A1_3p_x_at

Hs.147916.2.A2_3p_a_at

ILMN_1728870

ILMN_1794392

PH_hs_0028290

TC0X000199.hg

U50553_at

g13514812_3p_at

g13514816_3p_at

g3523149_3p_a_at

Participates

as a member of

Other forms of this molecule

DDX3X [secretory granule lumen]

DDX3X [ficolin-1-rich granule lumen]

Inferred To

bel [extracellular region] (Drosophila melanogaster)

ded1 [extracellular region] (Schizosaccharomyces pombe)

ddx3 [extracellular region] (Dictyostelium discoideum)

LOC100624590 [extracellular region] (Sus scrofa)

ddx3xb [extracellular region] (Danio rerio)

DDX3X [extracellular region] (Bos taurus)

DDX3X [extracellular region] (Canis familiaris)

DDX3X [extracellular region] (Gallus gallus)

DDX3X [extracellular region] (Plasmodium falciparum)

DDX3X [extracellular region] (Sus scrofa)

DED1 [extracellular region] (Saccharomyces cerevisiae)

Homologues of DDX3X [extracellular region] (Danio rerio)

Homologues of DDX3X [extracellular region] (Sus scrofa)

ddx3x [extracellular region] (Xenopus tropicalis)

Ddx3x [extracellular region] (Mus musculus)

Ddx3x [extracellular region] (Rattus norvegicus)

ddx3xa [extracellular region] (Danio rerio)

laf-1 [extracellular region] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001180346.1, NP_001347.3, NP_001180345.1

OpenTargets

ENSG00000215301

ZINC - Substances

DDX3X_HUMAN

ZINC target

O00571

PRO

O00571

PDB

4O2E, 2I4I, 4PX9, 4O2C, 6CZ5, 3JRV, 4O2F, 2JGN, 5E7M, 6O5F, 4PXA, 5E7J, 5E7I

GeneCards

O00571

HPA

ENSG00000215301-DDX3X

Ensembl

ENSP00000487224, ENST00000457138, ENSP00000486720, ENST00000630255, ENSP00000392494, ENSG00000215301, ENSP00000486516, ENSP00000494040, ENST00000629785, ENST00000478993, ENST00000629496, ENSP00000478443, ENST00000644876

Pharos - Targets

O00571

ZINC - Predictions - Purchasable

DDX3X_HUMAN

Orphanet

22249

HMDB Protein

HMDBP11672

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.789	10
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.775	7
UniProt:Q14164 IKBKE	4	IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.697	4
UniProt:P67809 YBX1	3	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.613	6
UniProt:P04608 tat	1	Tat (P04608) [nucleoplasm] (R-HIV-175856)	0.61	4
UniProt:Q9UBU9 NXF1	2	NXF1 [cytosol] (R-HSA-156481) NXF1 [nucleoplasm] (R-HSA-111690)	0.599	5
UniProt:Q04637 EIF4G1	2	p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-HSA-165762) EIF4G1 [cytosol] (R-HSA-72584)	0.557	3
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.543	4
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	10
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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