Reactome | PRDX4 [extracellular region]

PRDX4 [extracellular region]

Stable Identifier

R-HSA-6806512

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Peroxiredoxin-4 ecNumber1.11.1.15/ecNumber, PRDX4_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13162 PRDX4

Gene Names

PRDX4

Chain

signal peptide:1-37, chain:38-271

Reference Genes

BioGPS Gene:10549 PRDX4

COSMIC (genes):PRDX4 PRDX4

CTD Gene:10549 PRDX4

dbSNP Gene:10549 PRDX4

ENSEMBL:ENSG00000123131 PRDX4

HGNC:17169 PRDX4

KEGG:hsa:10549 PRDX4

Monarch:10549 PRDX4

NCBI Gene:10549 PRDX4

OMIM:300927 PRDX4

UCSC:Q13162 PRDX4

Reference Transcript

RefSeq:NM_006406.1 PRDX4

Other Identifiers

10549

11716060_at

17102111

201923_PM_at

201923_at

38435_at

3971769

3971770

3971772

3971773

3971774

3971775

3971776

3971778

3971779

3971780

3971781

3971783

3971785

3971786

3971789

3971791

3971792

8166455

A_23_P114232

A_33_P3272568

A_33_P3272573

GE59030

GO:0003824

GO:0004601

GO:0005515

GO:0005576

GO:0005634

GO:0005737

GO:0005783

GO:0005829

GO:0006457

GO:0006979

GO:0007252

GO:0007283

GO:0008379

GO:0008584

GO:0016209

GO:0016491

GO:0022414

GO:0022417

GO:0030198

GO:0034774

GO:0042744

GO:0042802

GO:0043226

GO:0045454

GO:0048856

GO:0051604

GO:0051920

GO:0060090

GO:0070062

GO:0072593

GO:0098754

GO:0098869

GO:0140313

GO:0140824

GO:1904813

GO:2000255

HMNXSV003012524

HMNXSV003020826

HMNXSV003053809

ILMN_2222234

PH_hs_0004762

TC0X000110.hg

U25182_at

g5453548_3p_at

Participates

as a member of

Other forms of this molecule

PRDX4 [ficolin-1-rich granule lumen]

PRDX4 [secretory granule lumen]

Inferred To

Homologues of PRDX4 [extracellular region] (Saccharomyces cerevisiae)

Prx4 [extracellular region] (Drosophila melanogaster)

tpx1 [extracellular region] (Schizosaccharomyces pombe)

Prdx4 [extracellular region] (Mus musculus)

Prdx4 [extracellular region] (Rattus norvegicus)

prdx4 [extracellular region] (Danio rerio)

prdx4 [extracellular region] (Dictyostelium discoideum)

prdx4 [extracellular region] (Xenopus tropicalis)

PRDX4 [extracellular region] (Bos taurus)

PRDX4 [extracellular region] (Canis familiaris)

PRDX4 [extracellular region] (Gallus gallus)

PRDX4 [extracellular region] (Saccharomyces cerevisiae)

PRDX4 [extracellular region] (Sus scrofa)

TSA2 [extracellular region] (Saccharomyces cerevisiae)

Cross References

ENSEMBL

ENSP00000368646, ENST00000379341

OpenTargets

ENSG00000123131

HPA

ENSG00000123131-PRDX4

PRO

Q13162

Pharos - Targets

Q13162

GlyGen

Q13162

HMDB Protein

HMDBP10108

PDB

3TKP, 3TKQ, 2PN8, 5HQP, 8EKY, 3TJB, 8EKW, 3TJF, 3TJG, 3TJJ, 3TJK, 3TKR, 4RQX, 3TKS

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18428 LBP	1	LBP [extracellular region] (R-HSA-166010)	0.602	4
UniProt:P21731 TBXA2R	1	TBXA2R [plasma membrane] (R-HSA-391837)	0.593	3
UniProt:Q06830 PRDX1	3	PRDX1 [cytosol] (R-HSA-3341270) HOOS-C52-PRDX1 [cytosol] (R-HSA-5629198) p-T90-PRDX1 [cytosol] (R-HSA-8868564)	0.573	2
UniProt:P22736 NR4A1	2	p-S351-NR4A1 [nucleoplasm] (R-HSA-199846) NR4A1 [nucleoplasm] (R-HSA-199831)	0.553	2
UniProt:Q15084 PDIA6	3	PDIA6 [endoplasmic reticulum lumen] (R-HSA-3009049) p-PDIA6 [endoplasmic reticulum lumen] (R-HSA-8957031) PDIA6 [endoplasmic reticulum membrane] (R-HSA-535530)	0.525	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	10

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