Reactome | LSM6 [nucleoplasm]

LSM6 [nucleoplasm]

Stable Identifier

R-HSA-6806794

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

U6 snRNA-associated Sm-like protein LSm6, LSM6_HUMAN

Locations in the PathwayBrowser

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Metabolism of RNA (Homo sapiens)

- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - mRNA Splicing (Homo sapiens)
    - mRNA Splicing - Major Pathway (Homo sapiens)
      - Formation of the Spliceosomal B complex (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        U4:U5:U6 tri-snRNP complex [nucleoplasm] (Homo sapiens)
        
        U4 snRNP:U6 snRNP complex [nucleoplasm] (Homo sapiens)
        
        U6 snRNP [nucleoplasm] (Homo sapiens)
        
        LSM2-8 complex [nucleoplasm] (Homo sapiens)
        
        LSM6 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Bact complex (Homo sapiens)
        
        LSM2-8 complex [nucleoplasm] (Homo sapiens)
        
        LSM6 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Pre-B complex (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        U4:U5:U6 tri-snRNP complex [nucleoplasm] (Homo sapiens)
        
        U4 snRNP:U6 snRNP complex [nucleoplasm] (Homo sapiens)
        
        U6 snRNP [nucleoplasm] (Homo sapiens)
        
        LSM2-8 complex [nucleoplasm] (Homo sapiens)
        
        LSM6 [nucleoplasm] (Homo sapiens)
        
        U4:U5:U6 tri-snRNP complex [nucleoplasm] (Homo sapiens)
        
        U4 snRNP:U6 snRNP complex [nucleoplasm] (Homo sapiens)
        
        U6 snRNP [nucleoplasm] (Homo sapiens)
        
        LSM2-8 complex [nucleoplasm] (Homo sapiens)
        
        LSM6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62312 LSM6

Gene Names

LSM6

Chain

chain:1-80

Reference Genes

BioGPS Gene:11157 LSM6

COSMIC (genes):LSM6 LSM6

CTD Gene:11157 LSM6

dbSNP Gene:11157 LSM6

ENSEMBL:ENSG00000164167 LSM6

ENSEMBL_homo_sapiens_GENE:ENSG00000164167.12 LSM6

HGNC:17017 LSM6

KEGG Gene (Homo sapiens):11157 LSM6

Monarch:11157 LSM6

NCBI Gene:11157 LSM6

OMIM:607286 LSM6

UCSC:P62312 LSM6

Reference Transcript

Other Identifiers

11157

11721137_a_at

11721138_x_at

16971226

205036_PM_at

205036_at

2746292

2746293

2746294

2746295

2746296

2746297

2746298

2746299

2746303

2746307

2746310

2746311

2746312

2746313

2746314

2746315

2746316

2746317

2746318

2746319

2746320

2746321

2746322

35991_at

3810955

8097679

A_14_P109721

A_23_P259451

GE55262

GO:0000398

GO:0000932

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005688

GO:0005730

GO:0005732

GO:0005737

GO:0005829

GO:0006364

GO:0006397

GO:0006399

GO:0006402

GO:0008033

GO:0008380

GO:0016071

GO:0030490

GO:0030532

GO:0042254

GO:0043226

GO:0043229

GO:0046540

GO:0046982

GO:0071005

GO:0120114

GO:0120115

GO:1990904

HMNXSV003040144

ILMN_1675462

PH_hs_0022666

PH_hs_0038133

TC04000717.hg

TC04002247.hg

g5901997_3p_at

Participates

as a component of

LSM2-8 complex [nucleoplasm] (Homo sapiens)

Other forms of this molecule

LSM6 [cytosol]

Inferred To

lsm6 [nucleoplasm] (Dictyostelium discoideum)

lsm6 [nucleoplasm] (Schizosaccharomyces pombe)

lsm6 [nucleoplasm] (Xenopus tropicalis)

LSM6 [nucleoplasm] (Bos taurus)

LSM6 [nucleoplasm] (Canis familiaris)

LSM6 [nucleoplasm] (Gallus gallus)

LSM6 [nucleoplasm] (Plasmodium falciparum)

LSM6 [nucleoplasm] (Sus scrofa)

Dmel\CG9344 [nucleoplasm] (Drosophila melanogaster)

Lsm6 [nucleoplasm] (Mus musculus)

Lsm6 [nucleoplasm] (Rattus norvegicus)

lsm-6 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_009011.1, XP_016863162.1, XP_016863161.1

OpenTargets

ENSG00000164167

GeneCards

P62312

HPA

ENSG00000164167-LSM6

Ensembl

ENST00000649747, ENSG00000164167, ENSP00000296581, ENSP00000422392, ENSP00000420929, ENST00000502781, ENST00000515311, ENSP00000497311, ENSP00000427036, ENST00000504181, ENST00000296581

PRO

P62312

Pharos - Targets

P62312

PDB

6QX9, 7ABG, 6AH0, 3JCR, 6QW6, 5O9Z, 6AHD

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.718	6
UniProt:P62316 SNRPD2	2	SNRPD2 [nucleoplasm] (R-HSA-71901) SNRPD2 [cytosol] (R-HSA-191810)	0.667	3