CARKD dehydrates S-NAD(P)HX to NADPH

Stable Identifier
R-HSA-6806967
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Human ATP-dependent (S)-NAD(P)H-hydrate dehydratase (CARKD) is thought to catalyze the dehydration, and thus repair, of the S-form of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. The human event is deduced on the basis of evidence from mouse experiments (Marbaix et al. 2011).

Literature References
PubMed ID Title Journal Year
21994945 Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair

Marbaix, AY, Noel, G, Detroux, AM, Vertommen, D, Van Schaftingen, E, Linster, CL

J. Biol. Chem. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ATP-dependent NAD(P)H-hydrate dehydratase activity of CARKD [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created