CARKD dehydrates S-NAD(P)HX to NADPH

Stable Identifier
R-HSA-6806967
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CARKD dehydrates S-NAD(P)HX to NADPH
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Human ATP-dependent (S)-NAD(P)H-hydrate dehydratase (CARKD) is thought to catalyze the dehydration, and thus repair, of the S-form of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. The human event is deduced on the basis of evidence from mouse experiments (Marbaix et al. 2011).

Literature References
PubMed ID Title Journal Year
21994945 Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair

Marbaix, AY, Noel, G, Detroux, AM, Vertommen, D, Van Schaftingen, E, Linster, CL

J. Biol. Chem. 2011
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ATP-dependent NAD(P)H-hydrate dehydratase activity of CARKD [mitochondrial matrix]
Physical Entity
CARKD [mitochondrial matrix]
Activity
ATP-dependent NAD(P)H-hydrate dehydratase activity (0047453)
Orthologous Events
CARKD dehydrates S-NAD(P)HX to NADPH (Bos taurus)
CARKD dehydrates S-NAD(P)HX to NADPH (Caenorhabditis elegans)
CARKD dehydrates S-NAD(P)HX to NADPH (Canis familiaris)
CARKD dehydrates S-NAD(P)HX to NADPH (Danio rerio)
CARKD dehydrates S-NAD(P)HX to NADPH (Dictyostelium discoideum)
CARKD dehydrates S-NAD(P)HX to NADPH (Drosophila melanogaster)
CARKD dehydrates S-NAD(P)HX to NADPH (Gallus gallus)
CARKD dehydrates S-NAD(P)HX to NADPH (Mus musculus)
CARKD dehydrates S-NAD(P)HX to NADPH (Plasmodium falciparum)
CARKD dehydrates S-NAD(P)HX to NADPH (Rattus norvegicus)
CARKD dehydrates S-NAD(P)HX to NADPH (Saccharomyces cerevisiae)
CARKD dehydrates S-NAD(P)HX to NADPH (Schizosaccharomyces pombe)
CARKD dehydrates S-NAD(P)HX to NADPH (Sus scrofa)
CARKD dehydrates S-NAD(P)HX to NADPH (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2015-10-28)
Reviewed
D'Eustachio, P  (2016-01-11)
Created
Jassal, B  (2015-10-28)
Cite Us!