Reactome | EBP isomerizes ZYMSTNL to LTHSOL

EBP isomerizes ZYMSTNL to LTHSOL

Stable Identifier

R-HSA-6807052

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

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EBP (3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase) associated with the endoplasmic reticulum membrane catalyzes the conversion of ZYMSTNL (zymostenol) to LTHSOL (lathosterol) (Braverman et al. 1999; Derry et al. 1999; Kandutsch & Russell 1960; Mitsche et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
14404284	Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol Russell, AE, Kandutsch, AA	J. Biol. Chem.	1960
10391219	Mutations in the gene encoding 3 beta-hydroxysteroid-delta 8, delta 7-isomerase cause X-linked dominant Conradi-Hunermann syndrome Wilcox, WR, Obie, C, Lin, P, Valle, D, Moser, A, Moebius, FF, Rimoin, DL, Glossmann, H, Braverman, N, Kratz, L, Kelley, RI, Smith, M	Nat Genet	1999
10391218	Mutations in a delta 8-delta 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. jderry@immunex.com. Boyd, Y, Herman, GE, Gormally, E, Zhao, W, Means, GD, Derry, JM, Kelley, RI, Meindl, A	Nat Genet	1999
26114596	Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways Hobbs, HH, Mitsche, MA, Cohen, JC, McDonald, JG	Elife	2015