Reactome | INTS8 [nucleoplasm]

INTS8 [nucleoplasm]

Stable Identifier

R-HSA-6807409

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Integrator complex subunit 8, INT8_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)
    - Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)
    - Integrator complex processes the 3' end of snRNA (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        INTS8 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q75QN2 INTS8

Gene Names

INTS8, C8orf52

Chain

chain:1-995

Reference Genes

BioGPS Gene:55656 INTS8

COSMIC (genes):INTS8 INTS8

CTD Gene:55656 INTS8

dbSNP Gene:55656 INTS8

ENSEMBL:ENSG00000164941 INTS8

ENSEMBL_homo_sapiens_GENE:ENSG00000164941.14 INTS8

HGNC:26048 INTS8

KEGG Gene (Homo sapiens):55656 INTS8

Monarch:55656 INTS8

NCBI Gene:55656 INTS8

OMIM:611351 INTS8

UCSC:Q75QN2 INTS8

Reference Transcript

Other Identifiers

11756772_a_at

17070998

218905_PM_at

218905_at

3107662

3107663

3107664

3107665

3107666

3107667

3107668

3107669

3107670

3107671

3107672

3107673

3107675

3107676

3107677

3107679

3107682

3107685

3107687

3107688

3107690

3107692

3107696

3107697

3107700

3107702

3107704

3107705

3107706

3107708

3107710

3107711

3107712

3107713

3107714

3107715

55656

58931_i_at

58932_r_at

61296_at

8147396

A_14_P113166

A_14_P138997

A_23_P43079

GO:0005515

GO:0005634

GO:0005654

GO:0006351

GO:0006355

GO:0016073

GO:0016180

GO:0032039

GO:0034243

GO:0034472

GO:0043226

HMNXSV003042643

ILMN_1759084

PH_hs_0024162

TC08000578.hg

g8923495_3p_at

Participates

as a component of

Integrator [nucleoplasm] (Homo sapiens)

Inferred To

INTS8 [nucleoplasm] (Bos taurus)

INTS8 [nucleoplasm] (Canis familiaris)

INTS8 [nucleoplasm] (Dictyostelium discoideum)

INTS8 [nucleoplasm] (Gallus gallus)

INTS8 [nucleoplasm] (Sus scrofa)

ints8 [nucleoplasm] (Xenopus tropicalis)

zgc:111823 [nucleoplasm] (Danio rerio)

IntS8 [nucleoplasm] (Drosophila melanogaster)

ints-8 [nucleoplasm] (Caenorhabditis elegans)

Ints8 [nucleoplasm] (Mus musculus)

Ints8 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_060334.2, XP_016869108.1

OpenTargets

ENSG00000164941

HPA

ENSG00000164941-INTS8

GeneCards

Q75QN2

Ensembl

ENST00000523731, ENSP00000430338, ENSG00000164941

PRO

Q75QN2

Pharos - Targets

Q75QN2

PDB

7PKS, 7CUN, 7YCX