Reactome | ASUN [nucleoplasm]

ASUN [nucleoplasm]

Stable Identifier

R-HSA-6807447

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Protein asunder homolog, ASUN_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA polymerase II transcribes snRNA genes (Homo sapiens)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)
    - Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)
    - Integrator complex processes the 3' end of snRNA (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
      - Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
        
        Integrator [nucleoplasm] (Homo sapiens)
        
        ASUN [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NVM9 ASUN

Gene Names

ASUN, C12orf11, GCT1, INTS13

Chain

chain:1-706

Reference Genes

BioGPS Gene:55726 ASUN

COSMIC (genes):INTS13 ASUN

CTD Gene:55726 ASUN

dbSNP Gene:55726 ASUN

ENSEMBL:ENSG00000064102 ASUN

HGNC:20174 ASUN

KEGG:hsa:55726 ASUN

Monarch:55726 ASUN

NCBI Gene:55726 ASUN

OMIM:615079 ASUN

UCSC:Q9NVM9 ASUN

Reference Transcript

Other Identifiers

11744221_a_at

11744907_a_at

16762573

221652_PM_s_at

221652_s_at

3448429

3448430

3448431

3448432

3448435

3448436

3448439

3448440

3448441

3448442

3448443

3448444

3448445

3448446

3448447

3448448

3448449

3448450

3448451

3448452

3448453

3448454

3448455

3448456

3448457

3448458

3448459

3448460

3448461

3448462

55726

56315_at

72373_at

7961964

A_23_P36464

A_33_P3232280

GE82312

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0006355

GO:0007010

GO:0007018

GO:0007052

GO:0007346

GO:0016073

GO:0016180

GO:0016604

GO:0022414

GO:0030317

GO:0032039

GO:0034243

GO:0043226

GO:0043231

GO:0048870

GO:0051301

GO:0051642

GO:0080154

GO:0090435

HMNXSV003047217

HMNXSV003049385

ILMN_2196335

ILMN_2196337

PH_hs_0001978

TC12001330.hg

g12751064_3p_a_at

Participates

as a component of

Integrator [nucleoplasm] (Homo sapiens)

Inferred To

C5H12ORF11 [nucleoplasm] (Bos taurus)

INTS13 [nucleoplasm] (Canis familiaris)

INTS13 [nucleoplasm] (Gallus gallus)

INTS13 [nucleoplasm] (Sus scrofa)

ASUN [nucleoplasm] (Dictyostelium discoideum)

Ints13 [nucleoplasm] (Rattus norvegicus)

IntS13 [nucleoplasm] (Mus musculus)

ints-13 [nucleoplasm] (Caenorhabditis elegans)

Homologues of ASUN [nucleoplasm] (Xenopus tropicalis)

Asun [nucleoplasm] (Drosophila melanogaster)

ints13 [nucleoplasm] (Danio rerio)

ints13 [nucleoplasm] (Xenopus tropicalis)

Cross References

ENSEMBL

ENST00000261191, ENSP00000261191, ENSG00000064102

OpenTargets

ENSG00000064102

GeneCards

INTS13

HPA

ENSG00000064102-INTS13

PRO

Q9NVM9

Pharos - Targets

Q9NVM9

GlyGen

Q9NVM9

PDB

8PK6, 8RBZ, 6SN1, 9EOC, 9FA7, 9FA4, 8PK5, 8RC4, 8RBX, 9EP1

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13951 CBFB	1	CBFB [nucleoplasm] (R-HSA-8865293)	0.524	2