NOX4, NOX5 reduce O2 to O2.-

Stable Identifier
R-HSA-6807557
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

NADPH oxidases 4 and 5 (NOX4, 5) are ER membrane-bound proteins that generates superoxide (O2.-) in endothelial cells (BelAiba et al. 2007). NOX4 functions in association with cytochrome b heterodimer (CYBA:CYBB) on the ER (and nuclear) membrane (Martyn et al. 2006).

Literature References
PubMed ID Title Journal Year
17275676 NOX5 variants are functionally active in endothelial cells

BelAiba, RS, Djordjevic, T, Petry, A, Diemer, K, Bonello, S, Banfi, B, Hess, J, Pogrebniak, A, Bickel, C, Görlach, A

Free Radic. Biol. Med. 2007
15927447 Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases

Martyn, KD, Frederick, LM, von Loehneysen, K, Dinauer, MC, Knaus, UG

Cell. Signal. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
superoxide-generating NADPH oxidase activity of NOX4, NOX5 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed