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ARF5 [cytosol]
Stable Identifier
R-HSA-6807737
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
Active ARF recruits coatomer (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
GBF1 recruits ARF:GDP to the ERGIC (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
GBF1 stimulates ARF nucleotide exchange (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
Active ARF recruits coatomer (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
GBF1 recruits ARF:GDP to the ERGIC (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
GBF1 stimulates ARF nucleotide exchange (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Golgi-to-ER retrograde transport (Homo sapiens)
COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
Active ARF recruits coatomer to the Golgi (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
GBF1 recruits ARF:GDP to the Golgi (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GDP [Golgi membrane] (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
GBF1 stimulates nucleotide exchange on ARF (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GDP [Golgi membrane] (Homo sapiens)
ARF:GDP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Homo sapiens)
ARF:GTP [cytosol] (Homo sapiens)
ARFs [cytosol] (Homo sapiens)
ARF5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P84085 ARF5
Gene Names
ARF5
Chain
initiator methionine:, chain:2-180
Reference Genes
BioGPS Gene:381 ARF5
COSMIC (genes):ARF5 ARF5
CTD Gene:381 ARF5
dbSNP Gene:381 ARF5
ENSEMBL:ENSG00000004059 ARF5
ENSEMBL_homo_sapiens_GENE:ENSG00000004059.11 ARF5
HGNC:658 ARF5
KEGG Gene (Homo sapiens):381 ARF5
Monarch:381 ARF5
NCBI Gene:381 ARF5
OMIM:103188 ARF5
UCSC:P84085 ARF5
Reference Transcript
RefSeq:NM_001662.3 ARF5
Other Identifiers
11735695_a_at
11744871_a_at
11744872_x_at
11754156_x_at
201526_PM_at
201526_at
3022410
3022411
3022414
3022416
3022418
3022419
3022420
3022421
37346_at
381
8135856
A_33_P3260777
GE79090
GO:0000166
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005576
GO:0005615
GO:0005737
GO:0005794
GO:0005886
GO:0006886
GO:0006890
GO:0015031
GO:0016020
GO:0016192
GO:0016787
GO:0043226
GO:0048471
GO:0070062
HMNXSV003046135
ILMN_1752340
M57567_at
PH_hs_0019930
PH_hs_0035952
TC07002566.hg
TC07003341.hg
g6995999_3p_at
g6995999_3p_x_at
Participates
as a candidate of
ARFs [cytosol] (Homo sapiens)
Inferred To
arrA [cytosol]
(Dictyostelium discoideum)
arrE [cytosol]
(Dictyostelium discoideum)
DKEY-238C7.11 [cytosol]
(Danio rerio)
arf-3 [cytosol]
(Caenorhabditis elegans)
arrD [cytosol]
(Dictyostelium discoideum)
arf5 [cytosol]
(Danio rerio)
Homologues of ARF5 [cytosol]
(Danio rerio)
Homologues of ARF5 [cytosol]
(Dictyostelium discoideum)
Homologues of ARF5 [cytosol]
(Plasmodium falciparum)
Homologues of ARF5 [cytosol]
(Saccharomyces cerevisiae)
ARF5 [cytosol]
(Bos taurus)
ARF5 [cytosol]
(Canis familiaris)
ARF5 [cytosol]
(Dictyostelium discoideum)
ARF5 [cytosol]
(Gallus gallus)
ARF5 [cytosol]
(Mus musculus)
ARF5 [cytosol]
(Plasmodium falciparum)
ARF5 [cytosol]
(Rattus norvegicus)
ARF5 [cytosol]
(Saccharomyces cerevisiae)
ARF5 [cytosol]
(Schizosaccharomyces pombe)
ARF5 [cytosol]
(Sus scrofa)
arrB [cytosol]
(Dictyostelium discoideum)
arrC [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001653.1
OpenTargets
ENSG00000004059
GeneCards
P84085
HPA
ENSG00000004059-ARF5
Ensembl
ENSG00000004059
,
ENST00000000233
,
ENSP00000000233
PRO
P84085
Pharos - Targets
P84085
PDB
2B6H
HMDB Protein
HMDBP08303
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WVK2 SNRNP27
1
SNRNP27 [nucleoplasm]
(R-HSA-6806778)
0.527
2
UniProt:P35414 APLNR
1
APLNR [plasma membrane]
(R-HSA-374259)
0.527
2
UniProt:Q9UHF4 IL20RA
1
IL20RA [plasma membrane]
(R-HSA-448713)
0.527
2
UniProt:Q9UNA3 A4GNT
1
A4GNT [Golgi membrane]
(R-HSA-5694499)
0.527
2
UniProt:P56559 ARL4C
1
ARL4C [plasma membrane]
(R-HSA-9618406)
0.527
2
UniProt:Q9Y5M8 SRPRB
1
SRPRB [endoplasmic reticulum membrane]
(R-HSA-265002)
0.527
2
UniProt:O94955 RHOBTB3
1
RHOBTB3 [trans-Golgi network membrane]
(R-HSA-6813908)
0.527
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
12
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