Reactome: A Curated Pathway Database

LDHAL6B reduces PYR to LACT

Stable Identifier
R-HSA-6807826
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

LDHAL6B (L-lactate dehydrogenase A-like 6B) catalyzes the reaction of PYR (pyruvate) and NADH + H+ to form LACT (lactate) and NAD+. The LDHAL6B protein is the inferred product of an open reading frame transcribed in the testis (Wang et al. 2005). Its mitochondrial localization is inferred from the presence of a mitochondrial localization sequence at its amino terminus (Holmes and Goldberg 2009). A physiological role for lactate formation from the abundant pyruvate and NADH expected in rapidly respiring mitochondria is not straightforward to imagine, however.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
L-lactate dehydrogenase activity of LDHAL6B [mitochondrial matrix] LDHAL6B [mitochondrial matrix] L-lactate dehydrogenase activity (0004459)
Orthologous Events