LDHAL6B reduces PYR to LACT

Stable Identifier
R-HSA-6807826
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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LDHAL6B (L-lactate dehydrogenase A-like 6B) catalyzes the reaction of PYR (pyruvate) and NADH + H+ to form LACT (lactate) and NAD+. The LDHAL6B protein is the inferred product of an open reading frame transcribed in the testis (Wang et al. 2005). Its mitochondrial localization is inferred from the presence of a mitochondrial localization sequence at its amino terminus (Holmes and Goldberg 2009). A physiological role for lactate formation from the abundant pyruvate and NADH expected in rapidly respiring mitochondria is not straightforward to imagine, however.

Literature References
PubMed ID Title Journal Year
15870898 Cloning and characterization of a novel intronless lactate dehydrogenase gene in human testis

Wang, H, Zhou, Z, Lu, L, Xu, Z, Sha, J

Int. J. Mol. Med. 2005
19679512 Computational analyses of mammalian lactate dehydrogenases: human, mouse, opossum and platypus LDHs

Holmes, RS, Goldberg, E

Comput Biol Chem 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
L-lactate dehydrogenase activity of LDHAL6B [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created