COPI-mediated anterograde transport

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

The ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2005; reviewed in Szul and Sztul, 2011). The ERGIC concentrates COPII-derived cargo from the ER for further anterograde transport to the cis-Golgi and also recycles resident ER proteins back to the ER through retrograde traffic. Both of these pathways appear to make use of microtubule-directed COPI-coated vesicles (Pepperkok et al, 1993; Presley et al, 1997; Scales et al, 1997; Stephens and Pepperkok, 2002; Stephens et al, 2000; reviewed in Lord et al, 2001; Spang et al, 2013).

Literature References
PubMed ID Title Journal Year
10825291 COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites

Stephens, DJ, Lin-Marq, N, Pagano, A, Pepperkok, R, Paccaud, JP

J Cell Sci 2000
22013193 COPII and COPI traffic at the ER-Golgi interface

Szul, T, Sztul, E

Physiology (Bethesda) 2011
8334707 Beta-COP is essential for biosynthetic membrane transport from the endoplasmic reticulum to the Golgi complex in vivo

Pepperkok, R, Scheel, J, Horstmann, H, Hauri, HP, Griffiths, G, Kreis, TE

Cell 1993
9288971 ER-to-Golgi transport visualized in living cells

Presley, JF, Cole, NB, Schroer, TA, Hirschberg, K, Zaal, KJ, Lippincott-Schwartz, J

Nature 1997
23732476 Retrograde traffic from the Golgi to the endoplasmic reticulum

Spang, A

Cold Spring Harb Perspect Biol 2013
9323141 Visualization of ER-to-Golgi transport in living cells reveals a sequential mode of action for COPII and COPI

Scales, SJ, Pepperkok, R, Kreis, TE

Cell 1997
23378591 The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi

Lord, C, Ferro-Novick, S, Miller, EA

Cold Spring Harb Perspect Biol 2013
15632110 Live imaging of bidirectional traffic from the ERGIC

Ben-Tekaya, H, Miura, K, Pepperkok, R, Hauri, HP

J. Cell. Sci. 2005
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