Reactome | ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG

ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG

Stable Identifier

R-HSA-6808487

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG

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ALDH1L2 (mitochondrial 10-formyltetrahydrofolate dehydrogenase) catalyzes the NADP-dependent dehydrogenation of 10-formyl-THFPG (10-formyltetrahydrofolate polyglutamate) to THFPG (tetrahydrofolate polyglutamate). This reaction has the effect of depleting the pool of folate charged with 1-carbon groups and might thus serve to regulate the size of the pool and the overall pace of mitochondrial biosynthetic reactions dependent on it (Krupenko et al. 2010; Strickland et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21238436	Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase Hu, CJ, Krupenko, SA, Krupenko, NI, Tsybovsky, Y, Strickland, KC, Dubard, ME	Chem. Biol. Interact.	2011
20498374	ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase Moxley, KM, Oleinik, NV, Krupenko, SA, Krupenko, NI, Strickland, KC, Dubard, ME	J. Biol. Chem.	2010