ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG

Stable Identifier
R-HSA-6808487
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

ALDH1L2 (mitochondrial 10-formyltetrahydrofolate dehydrogenase) catalyzes the NADP-dependent dehydrogenation of 10-formyl-THFPG (10-formyltetrahydrofolate polyglutamate) to THFPG (tetrahydrofolate polyglutamate). This reaction has the effect of depleting the pool of folate charged with 1-carbon groups and might thus serve to regulate the size of the pool and the overall pace of mitochondrial biosynthetic reactions dependent on it (Krupenko et al. 2010; Strickland et al. 2011).

Literature References
PubMed ID Title Journal Year
20498374 ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase

Krupenko, NI, Dubard, ME, Strickland, KC, Moxley, KM, Oleinik, NV, Krupenko, SA

J. Biol. Chem. 2010
21238436 Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase

Strickland, KC, Krupenko, NI, Dubard, ME, Hu, CJ, Tsybovsky, Y, Krupenko, SA

Chem. Biol. Interact. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aldehyde dehydrogenase (NAD) activity of ADH1L2 tetramer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed