Reactome: A Curated Pathway Database

ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG

Stable Identifier
R-HSA-6808487
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

ALDH1L2 (mitochondrial 10-formyltetrahydrofolate dehydrogenase) catalyzes the NADP-dependent dehydrogenation of 10-formyl-THFPG (10-formyltetrahydrofolate polyglutamate) to THFPG (tetrahydrofolate polyglutamate). This reaction has the effect of depleting the pool of folate charged with 1-carbon groups and might thus serve to regulate the size of the pool and the overall pace of mitochondrial biosynthetic reactions dependent on it (Krupenko et al. 2010; Strickland et al. 2011).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
aldehyde dehydrogenase (NAD) activity of ADH1L2 tetramer [mitochondrial matrix] ADH1L2 tetramer [mitochondrial matrix] aldehyde dehydrogenase (NAD) activity (0004029)
Orthologous Events