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ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG

Stable Identifier
R-HSA-6808496
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

ALDH1L1 (cytosolic 10-formyltetrahydrofolate dehydrogenase) catalyzes the NADP-dependent dehydrogenation of 10-formyl-THFPG (10-formyltetrahydrofolate polyglutamate) to THFPG (tetrahydrofolate polyglutamate). This reaction has the effect of depleting the pool of folate charged with 1-carbon groups and might thus serve to regulate the size of the pool and the overall pace of cytosolic biosynthetic reactions dependent on it (Krupenko et al. 2010; Strickland et al. 2011).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aldehyde dehydrogenase (NAD) activity of ALDH1L1 tetramer [cytosol]
Physical Entity
Activity
Orthologous Events