Several CHGA-derived peptides such as vasostatin-1 (CHGA(19-94) ) and catestatin (CHGA(370-390)) display antimicrobial activities against bacteria, fungi and yeasts (Lugardon K et al. 2000; Briolat J et al. 2005; Radek KA et al. 2008; Aslam R et al. 2013; Shooshtarizadeh P et al. 2010). These peptides are found in biological fluids involved in defence mechanisms (human serum and saliva) and in supernatants of stimulated human neutrophils (Lugardon K et al. 2000; Briolat J et al. 2005). In addition, catestatin (CHGA(370-390) exhibits antimicrobial activity against skin pathogens suggesting a function in cutaneous antimicrobial defense (Radek KA et al. 2008). Biophysical and structural analysis of human catestatin and bovine cateslytin suggests that cationic CHGA-derived peptides interact with anionic phospholipids on the bacterial surface (Sugawara M et al. 2010; Jean-Francois F et al. 2008). However, It remains to be clarified whether catestatin functions as a pore-forming or cell-penetrating agent.
Marquette, A, Bechinger, B, Moraes, CM, Metz-Boutigue, MH, Resende, JM, Sugawara, M, Chich, JF
O'Connor, DT, Taupenot, L, Radek, KA, Niesman, IR, Gallo, RL, Hupe, M, Elias, PM, Mahata, SK, Lopez-Garcia, B
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