CHGA-derived peptide binds the bacterial cell surface

Stable Identifier
Homo sapiens
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Chromogranin A (CHGA) belongs to the granin family of acidic proteins enclosed in secretory vesicles of nervous, endocrine and immune cells. The proteolytic cleveages of specific CHGA sequences by the pro-hormone convertases generate bioactive fragments that exert a broad spectrum of regulatory activities by influencing the endocrine, cardiovascular and immune systems and affect glucose and calcium homeostasis (Helle KB et al. 2007; Aslam R et al. 2012; D'amico MA et al. 2014; Aung G et al. 2011; Tota B et al. 2014).

Several CHGA-derived peptides such as vasostatin-1 (CHGA(19-94) ) and catestatin (CHGA(370-390)) display antimicrobial activities against bacteria, fungi and yeasts (Lugardon K et al. 2000; Briolat J et al. 2005; Radek KA et al. 2008; Aslam R et al. 2013; Shooshtarizadeh P et al. 2010). These peptides are found in biological fluids involved in defence mechanisms (human serum and saliva) and in supernatants of stimulated human neutrophils (Lugardon K et al. 2000; Briolat J et al. 2005). In addition, catestatin (CHGA(370-390) exhibits antimicrobial activity against skin pathogens suggesting a function in cutaneous antimicrobial defense (Radek KA et al. 2008). Biophysical and structural analysis of human catestatin and bovine cateslytin suggests that cationic CHGA-derived peptides interact with anionic phospholipids on the bacterial surface (Sugawara M et al. 2010; Jean-Francois F et al. 2008). However, It remains to be clarified whether catestatin functions as a pore-forming or cell-penetrating agent.

Literature References
PubMed ID Title Journal Year
18185531 The neuroendocrine peptide catestatin is a cutaneous antimicrobial and induced in the skin after injury

Radek, KA, Lopez-Garcia, B, Hupe, M, Niesman, IR, Elias, PM, Taupenot, L, Mahata, SK, O'Connor, DT, Gallo, RL

J. Invest. Dermatol. 2008
20103720 Membrane structure and interactions of human catestatin by multidimensional solution and solid-state NMR spectroscopy

Sugawara, M, Resende, JM, Moraes, CM, Marquette, A, Chich, JF, Metz-Boutigue, MH, Bechinger, B

FASEB J. 2010
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