Reactome | ARCN1 [Golgi membrane]

ARCN1 [Golgi membrane]

Stable Identifier

R-HSA-6808714

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Coatomer delta subunit

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [Golgi membrane] (Homo sapiens)
        
        tetrameric coatomer complex [Golgi membrane] (Homo sapiens)
        
        ARCN1 [Golgi membrane] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [Golgi membrane] (Homo sapiens)
        
        tetrameric coatomer complex [Golgi membrane] (Homo sapiens)
        
        ARCN1 [Golgi membrane] (Homo sapiens)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [Golgi membrane] (Homo sapiens)
        
        tetrameric coatomer complex [Golgi membrane] (Homo sapiens)
        
        ARCN1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [Golgi membrane] (Homo sapiens)
        
        tetrameric coatomer complex [Golgi membrane] (Homo sapiens)
        
        ARCN1 [Golgi membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - COPI vesicle uncoating (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [Golgi membrane] (Homo sapiens)
        
        tetrameric coatomer complex [Golgi membrane] (Homo sapiens)
        
        ARCN1 [Golgi membrane] (Homo sapiens)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [Golgi membrane] (Homo sapiens)
        
        tetrameric coatomer complex [Golgi membrane] (Homo sapiens)
        
        ARCN1 [Golgi membrane] (Homo sapiens)
      - cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [Golgi membrane] (Homo sapiens)
        
        tetrameric coatomer complex [Golgi membrane] (Homo sapiens)
        
        ARCN1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [Golgi membrane] (Homo sapiens)
        
        tetrameric coatomer complex [Golgi membrane] (Homo sapiens)
        
        ARCN1 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48444 ARCN1

Gene Names

ARCN1, COPD

Chain

initiator methionine:, chain:2-511

Reference Genes

BioGPS Gene:372 ARCN1

COSMIC (genes):ARCN1 ARCN1

CTD Gene:372 ARCN1

dbSNP Gene:372 ARCN1

ENSEMBL:ENSG00000095139 ARCN1

ENSEMBL_homo_sapiens_GENE:ENSG00000095139.15 ARCN1

HGNC:649 ARCN1

KEGG Gene (Homo sapiens):372 ARCN1

Monarch:372 ARCN1

NCBI Gene:372 ARCN1

OMIM:600820 ARCN1

UCSC:P48444 ARCN1

Reference Transcript

Other Identifiers

11736016_a_at

11741433_a_at

11755524_a_at

16731945

201176_PM_s_at

201176_s_at

3351533

3351537

3351538

3351539

3351540

3351541

3351543

3351544

3351546

3351549

3351550

3351551

3351552

3351553

3351554

3351555

3351556

3351557

34370_at

372

7944285

A_14_P118579

A_23_P203103

A_24_P201531

A_33_P3356216

GE61609

GO:0000139

GO:0003723

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0006886

GO:0006888

GO:0006890

GO:0008344

GO:0015031

GO:0016020

GO:0016192

GO:0021691

GO:0030126

GO:0030133

GO:0030137

GO:0030663

GO:0031410

GO:0043226

GO:0043473

GO:0048193

GO:0048856

GO:0051645

GO:0051649

HMNXSV003030790

HMNXSV003035118

ILMN_1699703

PH_hs_0002805

TC11001066.hg

X81198_at

g11863153_3p_a_at

Participates

as a component of

tetrameric coatomer complex [Golgi membrane] (Homo sapiens)

Other forms of this molecule

ARCN1 [endoplasmic reticulum membrane]

ARCN1 [transport vesicle]

ARCN1 [cytosol]

Inferred To

Arcn1 [Golgi membrane] (Mus musculus)

Arcn1 [Golgi membrane] (Rattus norvegicus)

copd-1 [Golgi membrane] (Caenorhabditis elegans)

copd [Golgi membrane] (Dictyostelium discoideum)

arcn1 [Golgi membrane] (Xenopus tropicalis)

ARCN1 [Golgi membrane] (Bos taurus)

ARCN1 [Golgi membrane] (Canis familiaris)

ARCN1 [Golgi membrane] (Gallus gallus)

ARCN1 [Golgi membrane] (Sus scrofa)

deltaCOP [Golgi membrane] (Drosophila melanogaster)

Ghost homologue of ARCN1 [Golgi membrane] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001135753.1, NP_001646.2

OpenTargets

ENSG00000095139

HPA

ENSG00000095139-ARCN1

GeneCards

P48444

Ensembl

ENSP00000376599, ENSG00000095139, ENST00000264028, ENSP00000264028, ENST00000392859

PRO

P48444

Pharos - Targets

P48444

Orphanet

24350

HMDB Protein

HMDBP08332

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	8
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3

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