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COG8 [Golgi membrane]
Stable Identifier
R-HSA-6808728
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG8 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG8 [Golgi membrane] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG8 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG8 [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG8 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG8 [Golgi membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG8 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG8 [Golgi membrane] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG8 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG8 [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG8 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG8 [Golgi membrane] (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Intra-Golgi traffic (Homo sapiens)
Formation of cis-SNARE complex and membrane fusion in intra-Golgi retrograde traffic (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG8 [Golgi membrane] (Homo sapiens)
COG complex:CUX1 dimer:GOLGA5 dimer:STX5:PalmC-YKT6:BET1L:GOSR1:intra-Golgi retrograde cargo [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG8 [Golgi membrane] (Homo sapiens)
The COG complex and CUX1 and GOLGA5 dimers contribute to intra-Golgi vesicle tethering (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG8 [Golgi membrane] (Homo sapiens)
COG complex:CUX1 dimer:GOLGA5 dimer:STX5:PalmC-YKT6:BET1L:GOSR1:intra-Golgi retrograde cargo [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG8 [Golgi membrane] (Homo sapiens)
The COG complex binds RABs at the Golgi membrane (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG8 [Golgi membrane] (Homo sapiens)
COG complex:RABs [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG8 [Golgi membrane] (Homo sapiens)
The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG8 [Golgi membrane] (Homo sapiens)
COG complex:Golgi snares [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG8 [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96MW5 COG8
Gene Names
COG8
Chain
chain:1-612
Reference Genes
BioGPS Gene:84342 COG8
COSMIC (genes):COG8 COG8
CTD Gene:84342 COG8
dbSNP Gene:84342 COG8
ENSEMBL:ENSG00000213380 COG8
ENSEMBL_homo_sapiens_GENE:ENSG00000213380.16 COG8
HGNC:18623 COG8
KEGG Gene (Homo sapiens):84342 COG8
Monarch:84342 COG8
NCBI Gene:84342 COG8
OMIM:606979 COG8
UCSC:Q96MW5 COG8
Reference Transcript
RefSeq:NM_032382.4 COG8
Other Identifiers
11724303_a_at
11758480_s_at
16827645
219575_PM_s_at
219575_s_at
238863_3p_x_at
238863_PM_x_at
238863_x_at
3696526
3696527
3696528
3696529
3696530
3696531
3696540
3696541
3696542
3696544
3696546
3696547
3696548
3696550
52271_s_at
59958_at
76522_at
8002272
84342
84778_at
A_23_P218295
A_23_P37966
A_23_P502057
A_24_P155815
A_32_P92399
A_33_P3287379
GE62896
GO:0000139
GO:0000301
GO:0005515
GO:0005794
GO:0006891
GO:0007030
GO:0015031
GO:0016020
GO:0016192
GO:0017119
GO:0032588
GO:0043226
GO:0070085
HMNXSV003052170
Hs.72322.0.A1_3p_at
Hs.72322.0.A1_3p_x_at
ILMN_1725246
PH_hs_0007726
PH_hs_0031711
PH_hs_0038787
TC16001220.hg
g11641242_3p_s_at
Participates
as a component of
COG complex [Golgi membrane] (Homo sapiens)
Other forms of this molecule
COG8 [trans-Golgi network membrane]
Inferred To
COG8 [Golgi membrane]
(Bos taurus)
COG8 [Golgi membrane]
(Canis familiaris)
COG8 [Golgi membrane]
(Gallus gallus)
COG8 [Golgi membrane]
(Rattus norvegicus)
COG8 [Golgi membrane]
(Sus scrofa)
cog8 [Golgi membrane]
(Dictyostelium discoideum)
cog8 [Golgi membrane]
(Schizosaccharomyces pombe)
cog8 [Golgi membrane]
(Xenopus tropicalis)
Cog8 [Golgi membrane]
(Drosophila melanogaster)
Cog8 [Golgi membrane]
(Mus musculus)
cogc-8 [Golgi membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_115758.3
OpenTargets
ENSG00000213380
HPA
ENSG00000213380-COG8
GeneCards
Q96MW5
Ensembl
ENSP00000305459
,
ENST00000306875
,
ENSG00000213380
PRO
Q96MW5
Pharos - Targets
Q96MW5
Orphanet
16432
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P55040 GEM
1
GEM [plasma membrane]
(R-HSA-9769962)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
12
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
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