Reactome | GORASP1 [Golgi membrane]

GORASP1 [Golgi membrane]

Stable Identifier

R-HSA-6808767

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

GRASP65, Golgi reassembly-stacking protein 1

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - COPI vesicle uncoating (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)
      - cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)
        
        GORASP1 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BQQ3 GORASP1

Gene Names

GORASP1, GOLPH5, GRASP65

Chain

initiator methionine:1, chain:2-440

Reference Genes

BioGPS Gene:64689 GORASP1

COSMIC (genes):GORASP1 GORASP1

CTD Gene:64689 GORASP1

dbSNP Gene:64689 GORASP1

ENSEMBL:ENSG00000114745 GORASP1

HGNC:16769 GORASP1

KEGG Gene (Homo sapiens):64689 GORASP1

Monarch:64689 GORASP1

NCBI Gene:64689 GORASP1

OMIM:606867 GORASP1

UCSC:Q9BQQ3 GORASP1

Reference Transcript

Other Identifiers

0000050286

11748326_a_at

11749903_s_at

11749904_x_at

11758146_s_at

16952383

215749_3p_s_at

215749_s_at

2669889

2669890

2669891

2669892

2669893

2669894

2669895

2669896

2669897

2669898

2669899

2669900

2669902

2669903

2669905

2669906

2669907

2669910

2669911

2669914

2669916

2669918

2669921

2669922

2669923

34812_at

64689

8086317

A_23_P427114

GE55833

GO:0000139

GO:0000902

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005794

GO:0006464

GO:0006487

GO:0006810

GO:0006888

GO:0007030

GO:0008150

GO:0009058

GO:0015031

GO:0016020

GO:0016192

GO:0022607

GO:0030154

GO:0033116

GO:0043167

GO:0043226

GO:0046872

GO:0048208

GO:0048856

GO:0050774

GO:0061024

GO:0061951

GO:0065003

GO:1904668

HMNXSV003000013

Hs.4291.1.S1_3p_a_at

Hs.4291.1.S1_3p_s_at

ILMN_1716821

PH_hs_0023232

TC03001301.hg

Participates

as a component of

GOLGA2:GORASP1 [Golgi membrane] (Homo sapiens)

Other forms of this molecule

GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane]

p-S189,T216,S274,S373-GORASP1 [Golgi membrane]

p-T216,S274,S373-GORASP1 [Golgi membrane]

Inferred To

GORASP1 [Golgi membrane] (Bos taurus)

GORASP1 [Golgi membrane] (Caenorhabditis elegans)

GORASP1 [Golgi membrane] (Canis familiaris)

GORASP1 [Golgi membrane] (Dictyostelium discoideum)

GORASP1 [Golgi membrane] (Gallus gallus)

GORASP1 [Golgi membrane] (Schizosaccharomyces pombe)

GORASP1 [Golgi membrane] (Sus scrofa)

gorasp1a [Golgi membrane] (Danio rerio)

Gorasp1 [Golgi membrane] (Mus musculus)

Gorasp1 [Golgi membrane] (Rattus norvegicus)

Grasp65 [Golgi membrane] (Drosophila melanogaster)

Ghost homologue of GORASP1 [Golgi membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001265718.1, NP_001265719.1, NP_114105.1

OpenTargets

ENSG00000114745

GeneCards

Q9BQQ3

HPA

ENSG00000114745-GORASP1

Ensembl

ENST00000431601, ENST00000319283, ENSG00000114745, ENSP00000313869, ENSP00000403552, ENSP00000403167, ENST00000452389

PRO

Q9BQQ3

Pharos - Targets

Q9BQQ3

PDB

6G8T, 4REY, 6G8W

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00116 AGPS	4	AGPS(1-658) [peroxisomal matrix] (R-HSA-9033523) AGPS(1-58) [peroxisomal matrix] (R-HSA-9033519) AGPS(1-658) [cytosol] (R-HSA-9033119) AGPS [peroxisomal matrix] (R-HSA-49699)	0.781	7
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.556	3

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