Reactome | TMED2 [transport vesicle]

TMED2 [transport vesicle]

Stable Identifier

R-HSA-6808806

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

transport vesicle

Synonyms

Transmembrane emp24 domain-containing protein 2, Membrane protein p24A, RNP24

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [transport vesicle] (Homo sapiens)
        
        TMED2:TMED10 tetramer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED2 dimer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [transport vesicle] (Homo sapiens)
        
        TMED2:TMED10 tetramer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED2 dimer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [transport vesicle] (Homo sapiens)
        
        TMED2:TMED10 tetramer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED2 dimer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [transport vesicle] (Homo sapiens)
        
        TMED2:TMED10 tetramer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED2 dimer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [transport vesicle] (Homo sapiens)
        
        TMED2:TMED10 tetramer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED2 dimer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [transport vesicle] (Homo sapiens)
        
        TMED2:TMED10 tetramer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED2 dimer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [transport vesicle] (Homo sapiens)
        
        TMED2:TMED10 tetramer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED2 dimer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [transport vesicle] (Homo sapiens)
        
        TMED2:TMED10 tetramer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED2 dimer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        Golgi-to-ER cargo [transport vesicle] (Homo sapiens)
        
        SURF4:p24 complex [transport vesicle] (Homo sapiens)
        
        TMED2 dimer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED2 dimer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        Golgi-to-ER cargo [transport vesicle] (Homo sapiens)
        
        SURF4:p24 complex [transport vesicle] (Homo sapiens)
        
        TMED2 dimer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED2 dimer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        Golgi-to-ER cargo [transport vesicle] (Homo sapiens)
        
        SURF4:p24 complex [transport vesicle] (Homo sapiens)
        
        TMED2 dimer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED2 dimer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        Golgi-to-ER cargo [transport vesicle] (Homo sapiens)
        
        SURF4:p24 complex [transport vesicle] (Homo sapiens)
        
        TMED2 dimer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)
        
        p24 dimers [transport vesicle] (Homo sapiens)
        
        TMED2 dimer [transport vesicle] (Homo sapiens)
        
        TMED2 [transport vesicle] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15363 TMED2

Gene Names

TMED2, RNP24

Chain

signal peptide:1-20, chain:21-201

Reference Genes

BioGPS Gene:10959 TMED2

COSMIC (genes):TMED2 TMED2

CTD Gene:10959 TMED2

dbSNP Gene:10959 TMED2

ENSEMBL:ENSG00000086598 TMED2

HGNC:16996 TMED2

KEGG:hsa:10959 TMED2

Monarch:10959 TMED2

NCBI Gene:10959 TMED2

OMIM:619642 TMED2

UCSC:Q15363 TMED2

Reference Transcript

Other Identifiers

10959

11751577_a_at

11756147_s_at

16650649

16650651

16650653

16650655

16650657

16650659

16650661

16650663

16650665

16650667

16650677

16758612

18670865

18670866

18670867

18670868

18670869

18670870

18670871

18670872

18670874

18670875

200087_PM_s_at

200087_s_at

204426_PM_at

204426_at

204427_PM_s_at

204427_s_at

3435854

3435855

3435856

3435857

3435858

3435859

3435860

3435861

3435862

3435863

3435864

3435865

3435867

3435869

3435871

36972_at

75058_f_at

7892799

7893200

7893733

7894292

7895347

7896142

7959597

A_23_P36445

A_23_P36448

A_33_P3301174

GE79821

GO:0000139

GO:0001701

GO:0001756

GO:0001843

GO:0001892

GO:0001893

GO:0001947

GO:0005109

GO:0005119

GO:0005515

GO:0005783

GO:0005789

GO:0005793

GO:0005794

GO:0006886

GO:0006888

GO:0006954

GO:0007029

GO:0007030

GO:0008104

GO:0009306

GO:0010628

GO:0012507

GO:0015031

GO:0016020

GO:0016192

GO:0022414

GO:0030133

GO:0030134

GO:0030137

GO:0030659

GO:0030663

GO:0031410

GO:0032525

GO:0032580

GO:0033116

GO:0034260

GO:0035264

GO:0035459

GO:0036342

GO:0036499

GO:0038024

GO:0042589

GO:0043226

GO:0043231

GO:0045879

GO:0048205

GO:0048208

GO:0048598

GO:0048856

GO:0060670

GO:0060716

GO:0060717

GO:0061024

GO:0065003

GO:0072595

GO:0072659

GO:0090158

GO:1903077

GO:1903912

GO:1905069

GO:2000638

HMNXSV003028336

Hs.75914.0.S1_3p_a_at

ILMN_1654939

PH_hs_0004385

TC12000988.hg

X92098_at

g5803148_3p_s_at

Participates

as a component of

Other forms of this molecule

TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane]

TMED2 [endoplasmic reticulum membrane]

TMED2 [ER to Golgi transport vesicle membrane]

TMED2 [Golgi membrane]

Inferred To

EMP24 [transport vesicle] (Saccharomyces cerevisiae)

CHOp24 [transport vesicle] (Drosophila melanogaster)

ERP2 [transport vesicle] (Saccharomyces cerevisiae)

ERP3 [transport vesicle] (Saccharomyces cerevisiae)

emp24 [transport vesicle] (Schizosaccharomyces pombe)

Ghost homologue of TMED2 [transport vesicle] (Danio rerio)

Homologues of TMED2 [transport vesicle] (Dictyostelium discoideum)

Homologues of TMED2 [transport vesicle] (Saccharomyces cerevisiae)

Homologues of TMED2 [transport vesicle] (Schizosaccharomyces pombe)

empB [transport vesicle] (Dictyostelium discoideum)

ERP4 [transport vesicle] (Saccharomyces cerevisiae)

Tmed2 [transport vesicle] (Mus musculus)

Tmed2 [transport vesicle] (Rattus norvegicus)

empA [transport vesicle] (Dictyostelium discoideum)

TMED2 [transport vesicle] (Bos taurus)

TMED2 [transport vesicle] (Canis familiaris)

TMED2 [transport vesicle] (Gallus gallus)

TMED2 [transport vesicle] (Plasmodium falciparum)

TMED2 [transport vesicle] (Schizosaccharomyces pombe)

TMED2 [transport vesicle] (Sus scrofa)

tmed2 [transport vesicle] (Xenopus tropicalis)

sel-9 [transport vesicle] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001308374.1, NP_006806.1

OpenTargets

ENSG00000086598

ENSEMBL

ENSP00000262225, ENST00000262225

HPA

ENSG00000086598-TMED2

PRO

Q15363

Pharos - Targets

Q15363

GlyGen

Q15363

PDB

5AZW

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49755 TMED10	5	TMED10 [Golgi membrane] (R-HSA-6808801) TMED10 [transport vesicle] (R-HSA-6808802) TMED10 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689845) TMED10 [ER to Golgi transport vesicle membrane] (R-HSA-5689843) TMED10 [endoplasmic reticulum membrane] (R-HSA-5689479)	0.905	11
UniProt:Q9Y3B3 TMED7	4	TMED7 [endoplasmic reticulum membrane] (R-HSA-6811014) TMED7 [Golgi membrane] (R-HSA-6808810) TMED7 [transport vesicle] (R-HSA-6808875) TMED7 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-6807776)	0.725	6
UniProt:P55085 F2RL1	1	F2RL1(37-397) [plasma membrane] (R-HSA-389418)	0.704	6
UniProt:O15260 SURF4	5	SURF4 [Golgi membrane] (R-HSA-6813912) SURF4 [transport vesicle] (R-HSA-6813919) SURF4 [endoplasmic reticulum membrane] (R-HSA-6813914) SURF4 [plasma membrane] (R-HSA-6806264) SURF4 [azurophil granule membrane] (R-HSA-6799361)	0.662	4
UniProt:Q9Y3A6 TMED5	1	TMED5 [endoplasmic reticulum membrane] (R-HSA-3247761)	0.643	5
UniProt:Q13445 TMED1			0.643	5
UniProt:Q9BVK6 TMED9	4	TMED9 [endoplasmic reticulum membrane] (R-HSA-6811016) TMED9 [Golgi membrane] (R-HSA-6808813) TMED9 [transport vesicle] (R-HSA-6808878) TMED9 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-6807777)	0.643	3
UniProt:P13987 CD59	8	CD59 [plasma membrane] (R-HSA-2530458) CD59 [specific granule membrane] (R-HSA-6799513) CD59 [tertiary granule membrane] (R-HSA-6800885) GPI-CD59 [endoplasmic reticulum membrane] (R-HSA-5689453) GPI-CD59 [ER to Golgi transport vesicle membrane] (R-HSA-5689801) GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689804) GPI-CD59 [transport vesicle] (R-HSA-6808775) GPI-CD59 [Golgi membrane] (R-HSA-6808772)	0.576	4
UniProt:P0DTD8 NS7B			0.547	2
UniProt:Q9H2A9 CHST8	1	CHST8 [Golgi membrane] (R-HSA-6786024)	0.527	3
UniProt:Q9Y5X9 LIPG	1	LIPG [extracellular region] (R-HSA-6789318)	0.527	2
UniProt:Q8TCS8 PNPT1	1	PNPT1 [mitochondrial matrix] (R-HSA-9836559)	0.527	3
UniProt:Q9H8Y8 GORASP2	2	p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965) GORASP2 [Golgi membrane] (R-HSA-2422385)	0.527	2
UniProt:Q8N441 FGFRL1	1	FGFRL1 [plasma membrane] (R-HSA-197650)	0.527	3
UniProt:Q14789 GOLGB1	3	GOLGB1(1-2893)-FLT3(591-993) fusion [cytosol] (R-HSA-9703322) GOLGB1(1-2893)-p-5Y-FLT3(591-993) fusion [cytosol] (R-HSA-9703303) GOLGB1 [Golgi membrane] (R-HSA-6810004)	0.527	4
UniProt:Q9Y3Q3 TMED3	4	TMED3 [endoplasmic reticulum membrane] (R-HSA-6811013) TMED3 [Golgi membrane] (R-HSA-6808809) TMED3 [transport vesicle] (R-HSA-6808874) TMED3 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-6807773)	0.527	4
UniProt:Q7Z7H5 TMED4			0.527	4
UniProt:Q9UQ80 PA2G4	2	PA2G4 [extracellular region] (R-HSA-6806200) PA2G4 [azurophil granule lumen] (R-HSA-6799205)	0.527	2
UniProt:Q96LL9 DJC30			0.527	2
UniProt:O75110 ATP9A	1	ATP9A [plasma membrane] (R-HSA-939754)	0.527	2
UniProt:O35587 TMEDA			0.524	2
UniProt:Q92542 NCSTN	3	NCSTN [plasma membrane] (R-HSA-2534241) NCSTN [azurophil granule membrane] (R-HSA-6799220) NCSTN [endosome membrane] (R-HSA-9010085)	0.524	2
UniProt:P41180 CASR	1	CASR [plasma membrane] (R-HSA-420719)	0.508	3
UniProt:P33535-4 OPRM1			0.463	2
UniProt:Q8WXF7 ATLA1			0.463	2
UniProt:P04618 rev	3	REV (P04618) protein [extracellular region] (R-HIV-174998) REV (P04618) protein [nucleoplasm] (R-HIV-175380) REV (P04618) protein [cytosol] (R-HIV-173267)	0.462	2