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TMED2 [transport vesicle]
Stable Identifier
R-HSA-6808806
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
transport vesicle
Synonyms
Transmembrane emp24 domain-containing protein 2, Membrane protein p24A, RNP24
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [transport vesicle] (Homo sapiens)
TMED2:TMED10 tetramer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
p24 dimers [transport vesicle] (Homo sapiens)
TMED2 dimer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [transport vesicle] (Homo sapiens)
TMED2:TMED10 tetramer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
p24 dimers [transport vesicle] (Homo sapiens)
TMED2 dimer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [transport vesicle] (Homo sapiens)
TMED2:TMED10 tetramer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
p24 dimers [transport vesicle] (Homo sapiens)
TMED2 dimer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [transport vesicle] (Homo sapiens)
TMED2:TMED10 tetramer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
p24 dimers [transport vesicle] (Homo sapiens)
TMED2 dimer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [transport vesicle] (Homo sapiens)
TMED2:TMED10 tetramer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
p24 dimers [transport vesicle] (Homo sapiens)
TMED2 dimer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [transport vesicle] (Homo sapiens)
TMED2:TMED10 tetramer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
p24 dimers [transport vesicle] (Homo sapiens)
TMED2 dimer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [transport vesicle] (Homo sapiens)
TMED2:TMED10 tetramer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
p24 dimers [transport vesicle] (Homo sapiens)
TMED2 dimer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)
TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [transport vesicle] (Homo sapiens)
TMED2:TMED10 tetramer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
p24 dimers [transport vesicle] (Homo sapiens)
TMED2 dimer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Golgi-to-ER retrograde transport (Homo sapiens)
COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
Golgi-to-ER cargo [transport vesicle] (Homo sapiens)
SURF4:p24 complex [transport vesicle] (Homo sapiens)
TMED2 dimer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
p24 dimers [transport vesicle] (Homo sapiens)
TMED2 dimer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
Golgi-to-ER cargo [transport vesicle] (Homo sapiens)
SURF4:p24 complex [transport vesicle] (Homo sapiens)
TMED2 dimer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
p24 dimers [transport vesicle] (Homo sapiens)
TMED2 dimer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
Golgi-to-ER cargo [transport vesicle] (Homo sapiens)
SURF4:p24 complex [transport vesicle] (Homo sapiens)
TMED2 dimer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
p24 dimers [transport vesicle] (Homo sapiens)
TMED2 dimer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
Golgi-to-ER cargo [transport vesicle] (Homo sapiens)
SURF4:p24 complex [transport vesicle] (Homo sapiens)
TMED2 dimer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
p24 dimers [transport vesicle] (Homo sapiens)
TMED2 dimer [transport vesicle] (Homo sapiens)
TMED2 [transport vesicle] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15363 TMED2
Gene Names
TMED2, RNP24
Chain
signal peptide:1-20, chain:21-201
Reference Genes
BioGPS Gene:10959 TMED2
COSMIC (genes):TMED2 TMED2
CTD Gene:10959 TMED2
dbSNP Gene:10959 TMED2
ENSEMBL:ENSG00000086598 TMED2
ENSEMBL:ENSG00000086598.11 TMED2
HGNC:16996 TMED2
KEGG Gene (Homo sapiens):10959 TMED2
Monarch:10959 TMED2
NCBI Gene:10959 TMED2
OMIM:619642 TMED2
Reference Transcript
RefSeq:NM_006815.3 TMED2
RefSeq:NM_001321445.1 TMED2
Other Identifiers
10959
11751577_a_at
11756147_s_at
16758612
18670865
18670866
18670867
18670869
18670870
18670871
18670874
18670875
200087_PM_s_at
200087_s_at
204426_PM_at
204426_at
204427_PM_s_at
204427_s_at
3435854
3435855
3435856
3435859
3435860
3435863
3435864
3435865
36972_at
75058_f_at
7893733
7895347
7896142
7959597
A_23_P36445
A_23_P36448
A_33_P3301174
GE79821
GO:0000139
GO:0001701
GO:0001756
GO:0001843
GO:0001892
GO:0001893
GO:0001947
GO:0005109
GO:0005119
GO:0005515
GO:0005783
GO:0005789
GO:0005793
GO:0005794
GO:0006886
GO:0006888
GO:0006954
GO:0007029
GO:0007030
GO:0008104
GO:0009306
GO:0010628
GO:0012507
GO:0015031
GO:0016020
GO:0016192
GO:0022414
GO:0023052
GO:0030133
GO:0030134
GO:0030137
GO:0030659
GO:0030663
GO:0031410
GO:0032525
GO:0032580
GO:0033116
GO:0034260
GO:0035264
GO:0035459
GO:0036211
GO:0036342
GO:0036499
GO:0042589
GO:0043226
GO:0043231
GO:0045879
GO:0048205
GO:0048208
GO:0048598
GO:0048856
GO:0060670
GO:0060716
GO:0060717
GO:0061024
GO:0065003
GO:0072595
GO:0072659
GO:0090158
GO:1901621
GO:1903077
GO:1903912
GO:1905069
GO:2000638
HMNXSV003028336
Hs.75914.0.S1_3p_a_at
ILMN_1654939
PH_hs_0004385
TC12000988.hg
X92098_at
g5803148_3p_s_at
Participates
as a component of
TMED2 dimer [transport vesicle] (Homo sapiens)
TMED2:TMED10 tetramer [transport vesicle] (Homo sapiens)
Other forms of this molecule
TMED2 [Golgi membrane]
TMED2 [ER to Golgi transport vesicle membrane]
TMED2 [endoplasmic reticulum membrane]
TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
Inferred To
EMP24 [transport vesicle]
(Saccharomyces cerevisiae)
CHOp24 [transport vesicle]
(Drosophila melanogaster)
ERP2 [transport vesicle]
(Saccharomyces cerevisiae)
ERP3 [transport vesicle]
(Saccharomyces cerevisiae)
emp24 [transport vesicle]
(Schizosaccharomyces pombe)
Homologues of TMED2 [transport vesicle]
(Dictyostelium discoideum)
Homologues of TMED2 [transport vesicle]
(Saccharomyces cerevisiae)
Homologues of TMED2 [transport vesicle]
(Schizosaccharomyces pombe)
empB [transport vesicle]
(Dictyostelium discoideum)
ERP4 [transport vesicle]
(Saccharomyces cerevisiae)
Tmed2 [transport vesicle]
(Mus musculus)
Tmed2 [transport vesicle]
(Rattus norvegicus)
empA [transport vesicle]
(Dictyostelium discoideum)
TMED2 [transport vesicle]
(Bos taurus)
TMED2 [transport vesicle]
(Canis familiaris)
TMED2 [transport vesicle]
(Danio rerio)
TMED2 [transport vesicle]
(Gallus gallus)
TMED2 [transport vesicle]
(Plasmodium falciparum)
TMED2 [transport vesicle]
(Schizosaccharomyces pombe)
TMED2 [transport vesicle]
(Sus scrofa)
tmed2 [transport vesicle]
(Xenopus tropicalis)
sel-9 [transport vesicle]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_006806.1
,
NP_001308374.1
OpenTargets
ENSG00000086598
GeneCards
Q15363
HPA
ENSG00000086598-TMED2
Ensembl
ENSG00000086598
,
ENSP00000262225
,
ENST00000262225
PRO
Q15363
Pharos - Targets
Q15363
PDB
5AZW
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49755 TMED10
5
TMED10 [Golgi membrane]
(R-HSA-6808801)
TMED10 [transport vesicle]
(R-HSA-6808802)
TMED10 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5689845)
TMED10 [ER to Golgi transport vesicle membrane]
(R-HSA-5689843)
TMED10 [endoplasmic reticulum membrane]
(R-HSA-5689479)
0.832
7
UniProt:P55085 F2RL1
1
F2RL1(37-397) [plasma membrane]
(R-HSA-389418)
0.704
6
UniProt:Q9Y3B3 TMED7
4
TMED7 [endoplasmic reticulum membrane]
(R-HSA-6811014)
TMED7 [Golgi membrane]
(R-HSA-6808810)
TMED7 [transport vesicle]
(R-HSA-6808875)
TMED7 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-6807776)
0.643
3
UniProt:P13987 CD59
8
CD59 [tertiary granule membrane]
(R-HSA-6800885)
CD59 [specific granule membrane]
(R-HSA-6799513)
GPI-CD59 [Golgi membrane]
(R-HSA-6808772)
GPI-CD59 [transport vesicle]
(R-HSA-6808775)
GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5689804)
GPI-CD59 [ER to Golgi transport vesicle membrane]
(R-HSA-5689801)
GPI-CD59 [endoplasmic reticulum membrane]
(R-HSA-5689453)
CD59 [plasma membrane]
(R-HSA-2530458)
0.576
4
UniProt:O15260 SURF4
5
SURF4 [Golgi membrane]
(R-HSA-6813912)
SURF4 [transport vesicle]
(R-HSA-6813919)
SURF4 [endoplasmic reticulum membrane]
(R-HSA-6813914)
SURF4 [plasma membrane]
(R-HSA-6806264)
SURF4 [azurophil granule membrane]
(R-HSA-6799361)
0.558
3
UniProt:P0DTD8 NS7B
0.547
2
UniProt:Q92542 NCSTN
3
NCSTN [endosome membrane]
(R-HSA-9010085)
NCSTN [plasma membrane]
(R-HSA-2534241)
NCSTN [azurophil granule membrane]
(R-HSA-6799220)
0.524
2
UniProt:O35587 TMEDA
0.524
2
UniProt:P41180 CASR
1
CASR [plasma membrane]
(R-HSA-420719)
0.508
3
UniProt:P33535-4 OPRM1
0.463
2
UniProt:Q8WXF7 ATLA1
0.463
2
UniProt:P04618 rev
3
REV (P04618) protein [extracellular region]
(R-HIV-174998)
REV (P04618) protein [nucleoplasm]
(R-HIV-175380)
REV (P04618) protein [cytosol]
(R-HIV-173267)
0.462
2
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