Reactome | NUDT14 [cytosol]

NUDT14 [cytosol]

Stable Identifier

R-HSA-6809220

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Uridine diphosphate glucose pyrophosphatase, NUD14_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of dolichyl-phosphate-glucose (Homo sapiens)
        
        NUDT14 hydrolyses UDP-Glc to G1P and UMP (Homo sapiens)
        
        NUDT14 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95848 NUDT14

Gene Names

NUDT14, UGPP

Chain

chain:1-222

Reference Genes

BioGPS Gene:256281 NUDT14

COSMIC (genes):NUDT14 NUDT14

CTD Gene:256281 NUDT14

dbSNP Gene:256281 NUDT14

ENSEMBL:ENSG00000183828 NUDT14

ENSEMBL_homo_sapiens_GENE:ENSG00000183828.15 NUDT14

HGNC:20141 NUDT14

KEGG Gene (Homo sapiens):256281 NUDT14

Monarch:256281 NUDT14

NCBI Gene:256281 NUDT14

OMIM:609219 NUDT14

UCSC:O95848 NUDT14

Reference Transcript

RefSeq:NM_177533.4 NUDT14

Other Identifiers

11726340_a_at

16797272

231914_PM_at

231914_at

256281

3581486

3581487

3581488

3581492

3581494

3581495

3581497

3581498

3581499

7981566

A_23_P414978

A_32_P5976

GO:0003824

GO:0005515

GO:0005737

GO:0005829

GO:0006486

GO:0006753

GO:0008768

GO:0016787

GO:0016818

GO:0018279

GO:0019693

GO:0036211

GO:0042802

GO:0046872

GO:0047631

GO:0055086

GO:1901135

HMNXSV003001418

HMNXSV003028058

Hs.306165.0.S1_3p_s_at

ILMN_1669788

TC14002334.hg

Inferred To

NUDT14 [cytosol] (Bos taurus)

NUDT14 [cytosol] (Caenorhabditis elegans)

NUDT14 [cytosol] (Gallus gallus)

NUDT14 [cytosol] (Sus scrofa)

si:dkey-77p13.2 [cytosol] (Danio rerio)

CG31063 [cytosol] (Drosophila melanogaster)

Nudt14 [cytosol] (Mus musculus)

Nudt14 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_803877.2

OpenTargets

ENSG00000183828

IntEnz

3.6.1.45

GeneCards

O95848

HPA

ENSG00000183828-NUDT14

Ensembl

ENST00000392568, ENSP00000376349, ENSG00000183828

PRO

O95848

Pharos - Targets

O95848

HMDB Protein

HMDBP01097

PDB

3Q91

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95848 NUDT14	1	NUDT14 [cytosol] (R-HSA-6809220)	0.742	5
UniProt:Q9GZT8 NIF3L			0.718	6
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.718	8
UniProt:Q96HA8 NTAQ1			0.666	4
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.556	3
UniProt:Q8TBK6 ZCH10			0.556	3
UniProt:Q96N21 AP4AT			0.556	3
UniProt:Q9NYB0 TERF2IP	1	TERF2IP [nucleoplasm] (R-HSA-174873)	0.508	2
UniProt:Q8N448 LNX2			0.488	2

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