PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane

Stable Identifier
R-HSA-6809320
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Formation of a complex with MTMR9 results in a 30-fold increase of phosphatidylinositol-(3,5)-bisphosphate 3-phosphatase catalytic activity of MTMR6 and a modest increase in the catalytic activity of MTMR8 (Zou et al. 2009, Zou et al. 2012).

Literature References
PubMed ID Title Journal Year
22647598 Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8

Zou, J, Zhang, C, Marjanovic, J, Kisseleva, MV, Majerus, PW, Wilson, MP

Proc. Natl. Acad. Sci. U.S.A. 2012
19038970 MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis

Zou, J, Chang, SC, Marjanovic, J, Majerus, PW

J. Biol. Chem. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity of MTMR6:MTMR9,MTMR8:MTMR9 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created