PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane

Stable Identifier
R-HSA-6809325
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Formation of a complex with MTMR9 results in a 4-fold increase of the phosphatidylinositol-3-phosphatase catalytic activity of MTMR8 and a modest increase of the catalytic activity of MTMR6 (Zou et al. 2012).

Literature References
PubMed ID Title Journal Year
22647598 Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8

Zou, J, Zhang, C, Marjanovic, J, Kisseleva, MV, Majerus, PW, Wilson, MP

Proc. Natl. Acad. Sci. U.S.A. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-3-phosphatase activity of MTMR6:MTMR9,MTMR8:MTMR9 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created