NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT

Stable Identifier
R-HSA-6809354
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
ReviewStatus
5/5
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NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT
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Coenzyme A (CoASH) is a necessary cofactor for the oxidation of lipids in peroxisomes. Peroxisomal coenzyme A diphosphatase (NUDT7) mediates the cleavage of CoA (and CoA esters and oxidised CoA) to produce 3',5'-ADP and 4'-phosphopantetheine (PPANT) and is suggested to be involved in the regulation of peroxisomal CoASH levels. Human NUDT7 activity is inferred from mouse Nudt7 activity (Gasmi et al. 2001, Reilly et al. 2008).
Literature References
PubMed ID Title Journal Year
18799520 The nudix hydrolase 7 is an Acyl-CoA diphosphatase involved in regulating peroxisomal coenzyme A homeostasis

Reilly, SJ, Alexson, SE, Tillander, V, Hunt, MC, Ofman, R

J. Biochem. 2008
11415433 The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives

Gasmi, L, McLennan, AG

Biochem. J. 2001
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Catalyst Activity

CoA pyrophosphatase activity of NUDT7 [peroxisomal matrix]

Physical Entity
NUDT7 [peroxisomal matrix] (Homo sapiens)
Activity
CoA pyrophosphatase activity (GO:0010945)
Inferred From
Nudt7 hydrolyses CoA-SH to 3',5'-ADP and PPANT (Mus musculus)
Authored
Jassal, B  (2015-11-11)
Reviewed
D'Eustachio, P  (2016-01-11)
Created
Jassal, B  (2015-11-11)
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