Reactome | SBF1 binds MTMR2

SBF1 binds MTMR2

Stable Identifier

R-HSA-6809764

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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MTMR2 forms a heterodimer with SBF1 (MTMR5), an enzymatically inactive myotubularin family member. The interaction of MTMR2 and SBF1 involves coiled-coil domains of both proteins. SBF1 promotes perinuclear localization of MTMR2 (Kim et al. 2003), presumably to the endoplasmic reticulum(ER) membrane, as both proteins can localize to the ER membrane (Berger et al. 2003, Li et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
25522275	SBF-1 exerts strong anticervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca(2+)-ATPase 2 Li, W, Xu, Q, Sun, Y, Gu, Y, Yu, B, Zhang, Q, Shu, Y, Shen, Y, Ouyang, Z, Wu, X, Wu, X, Wang, L	Cell Death Dis	2014
14530412	Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module Ban, N, Berger, I, Berger, P, Suter, U, Schaffitzel, C	Proc. Natl. Acad. Sci. U.S.A.	2003
12668758	Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase Vacratsis, PO, Kim, SA, Firestein, R, Cleary, ML, Dixon, JE	Proc. Natl. Acad. Sci. U.S.A.	2003