PI3P is dephosphorylated to PI by MTMR2:SBF1

Stable Identifier
R-HSA-6809777
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding to SBF1 (MTMR5) increases phosphatidylinositol-3-phosphatase catalytic activity of MTMR2 (Kim et al. 2003). SBF1 promotes perinuclear localization of MTMR2 (Kim et al. 2003), presumably to the endoplasmic reticulum (ER) membrane, as both proteins can localize to the ER membrane (Berger et al. 2003, Li et al. 2014).

Literature References
PubMed ID Title Journal Year
14530412 Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module

Berger, P, Schaffitzel, C, Berger, I, Ban, N, Suter, U

Proc. Natl. Acad. Sci. U.S.A. 2003
25522275 SBF-1 exerts strong anticervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca(2+)-ATPase 2

Li, W, Ouyang, Z, Zhang, Q, Wang, L, Shen, Y, Wu, X, Wu, X, Gu, Y, Shu, Y, Yu, B, Sun, Y, Xu, Q

Cell Death Dis 2014
12668758 Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase

Kim, SA, Vacratsis, PO, Firestein, R, Cleary, ML, Dixon, JE

Proc. Natl. Acad. Sci. U.S.A. 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-3-phosphatase activity of MTMR2:SBF1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created