PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA

Stable Identifier
R-HSA-6809810
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PECR associated with the peroxisomal membrane catalyzes the NADPH-dependent reduction of 2E-phytenoyl-CoA to form phytanoyl-CoA (Das et al. 2000; Gloerich et al. 2006). The active form of the enzyme is inferred to be a homotetramer from unpublished data deposited in PDB (accession 1YXM). This reaction is part of the process by which dietary phytol, ultimately derived from chlorophyll, is catabolized (Van Veldhoven 2010).

Literature References
PubMed ID Title Journal Year
20558530 Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism

Van Veldhoven, PP

J. Lipid Res. 2010
16546181 Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation

Gloerich, J, Ruiter, JP, van den Brink, DM, Ofman, R, Ferdinandusse, S, Wanders, RJ

FEBS Lett. 2006
10811639 Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs

Das, AK, Uhler, MD, Hajra, AK

J. Biol. Chem. 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
trans-2-enoyl-CoA reductase (NADPH) activity of PECR tetramer [peroxisomal membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
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