PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane

Stable Identifier
R-HSA-6809944
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Formation of a complex with SBF2 (MTMR13) dramatically increases phosphatidylinositol-(3,5)-bisphosphate 3-phosphatase catalytic activity of MTMR2. Since SBF2 sequesters MTRM2 from endosome membranes, the MTMR2 presumably acts on the plasma membrane-associated substrate (Berger et al. 2006).

Literature References
PubMed ID Title Journal Year
16399794 Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2

Berger, P, Berger, I, Schaffitzel, C, Tersar, K, Volkmer, B, Suter, U

Hum. Mol. Genet. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity of MTMR2:SBF2 Tetramer [cytosol]
Physical Entity
Activity
Inferred From
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Created