HOXB2 chromatin is activated

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R-HSA-6810159
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Reaction [omitted]
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Homo sapiens
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During activation of HOXB1 by retinoic acid in human embryonal carcinoma cells, methylation at lysine-27 of histone H3 (H3K27me3) is lost and methylation at lysine-4 (H3K4me3) is gained (Lan et al. 2007, Lee et al. 2007). The histone demethylase KDM6A (UTX) binds HOXB2 chromatin and may demethylate H3K27me3 (Lee et al. 2007). Other factors may also participate in demethylation. Loss of H3K27me3 is associated with loss of polycomb repressive complex 2 (PRC2) (Lan et al. 2007, Lee et al. 2007). KDM6A forms complexes with the histone methyltransferases KMT2C,D (MLL2,3) which may participate in methylating H3K4 (Lee et al. 2007). The activation of HOXB1 chromatin may be produced by euchromatin spreading from distant 3' retinoic acid response elements.

Literature References
PubMed ID Title Journal Year
17761849 Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination

Lee, MG, Villa, R, Trojer, P, Norman, J, Yan, KP, Reinberg, D, Di Croce, L, Shiekhattar, R

Science 2007
17851529 A histone H3 lysine 27 demethylase regulates animal posterior development

Lan, F, Bayliss, PE, Rinn, JL, Whetstine, JR, Wang, JK, Chen, S, Iwase, S, Alpatov, R, Issaeva, I, Canaani, E, Roberts, TM, Chang, HY, Shi, Y

Nature 2007
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