HOXA3 chromatin is activated

Stable Identifier
R-HSA-6810161
Type
Reaction [omitted]
Species
Homo sapiens
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In human fibroblasts (Lan et al. 2007) and human embryonic carcinoma cells (Lee et al. 2007, Sessa et al. 2007) treated with retinoic acid HOXA3 chromatin is activated by loss of methylation at lysine-27 of histone H3 (H3K27me3) and gain of H3K4me3. KDM6A (UTX) binds near HOXA3 (Lan et al. 2007, Lee et al. 2007) but does not appear to participate in the loss of H3K27me3. KDM6A forms complexes with the histone methyltransferases KMT2C,D (MLL2,3) which may participate in methylating H3K4 (Lee et al. 2007). Polycomb repressive complex 2 (PRC2), which binds H3K27me3, is also lost during activation of HOXA3 (Lan et al. 2007, Lee et al. 2007, Sessa et al. 2007). The change in chromatin at HOXA3 may result from euchromatin spreading from distant 3' retinoic acid response elements. The chromosomal conformation of the entire HOXA cluster changes during activation (Rousseau et al. 2014).

Literature References
PubMed ID Title Journal Year
25135475 CTCF Controls HOXA Cluster Silencing and Mediates PRC2-Repressive Higher-Order Chromatin Structure in NT2/D1 Cells

Xu, M, Zhao, GN, Lv, X, Liu, G, Wang, LY, Hao, DL, Wang, J, Liu, DP, Liang, CC

Mol. Cell. Biol. 2014
24174538 Hox in motion: tracking HoxA cluster conformation during differentiation

Rousseau, M, Crutchley, JL, Miura, H, Suderman, M, Blanchette, M, Dostie, J

Nucleic Acids Res. 2014
17851529 A histone H3 lysine 27 demethylase regulates animal posterior development

Lan, F, Bayliss, PE, Rinn, JL, Whetstine, JR, Wang, JK, Chen, S, Iwase, S, Alpatov, R, Issaeva, I, Canaani, E, Roberts, TM, Chang, HY, Shi, Y

Nature 2007
17185360 Noncoding RNA synthesis and loss of Polycomb group repression accompanies the colinear activation of the human HOXA cluster

Sessa, L, Breiling, A, Lavorgna, G, Silvestri, L, Casari, G, Orlando, V

RNA 2007
17761849 Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination

Lee, MG, Villa, R, Trojer, P, Norman, J, Yan, KP, Reinberg, D, Di Croce, L, Shiekhattar, R

Science 2007
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