Fillagrin and keratin intermediate filaments polymerise forming a network

Stable Identifier
R-HSA-6810357
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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During cornification a network of keratin intermediate filaments (KIF) and filaggrin (FLG) becomes crosslinked to the cornified envelope (CE). This facilitates the collapse and flattening of cells in the outermost stratum corneum to produce squames (Dale et al. 1978, Mack et al. 1993, Candi et al. 2005, Gruber et al. 2011).

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