ING2 binds PI5P

Stable Identifier
R-HSA-6810376
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The PHD finger of ING2 binds phosphatidylinositol-5-phosphate (PI5P) (Gozani et al. 2003), which promotes nuclear retention of ING2 (Jones et al. 2006, Zou et al. 2007).

Literature References
PubMed ID Title Journal Year
16949365 Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta

Jones, DR, Bultsma, Y, Keune, WJ, Halstead, JR, Elouarrat, D, Mohammed, S, Heck, AJ, D'Santos, CS, Divecha, N

Mol. Cell 2006
17940011 Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis

Zou, J, Marjanovic, J, Kisseleva, MV, Wilson, M, Majerus, PW

Proc. Natl. Acad. Sci. U.S.A. 2007
12859901 The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor

Gozani, O, Karuman, P, Jones, DR, Ivanov, D, Cha, J, Lugovskoy, AA, Baird, CL, Zhu, H, Field, SJ, Lessnick, SL, Villasenor, J, Mehrotra, B, Chen, J, Rao, VR, Brugge, JS, Ferguson, CG, Payrastre, B, Myszka, DG, Cantley, LC, Wagner, G, Divecha, N, Prestwich, GD, Yuan, J

Cell 2003
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