PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus

Stable Identifier
R-HSA-6810410
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Translocation of TMEM55B (type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase) to the nucleus under conditions of cellular stress leads to dephosphorylation of nuclear PI(4,5)P2 to PI5P, thus increasing the concentration of PI5P in the nucleus (Zou et al. 2007). PIP2 and its derivatives are not associated with nuclear envelope structures (Bornenkov et al. 1998) but localize to poorly defined subnuclear compartments called nuclear specks (reviewed by Barlow et al. 2010).

Literature References
PubMed ID Title Journal Year
17940011 Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis

Zou, J, Marjanovic, J, Kisseleva, MV, Wilson, M, Majerus, PW

Proc. Natl. Acad. Sci. U.S.A. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity of TMEM55B [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created