NUDT13 hydrolyses AP6A to AP4 and ADP

Stable Identifier
R-HSA-6810472
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Mitochondrial Nudix hydrolase 13 (NUDT13) is able to hydrolyse long-chain diadenosine polyphosphates such as diadenosine hexaphosphate (AP6A) to ADP and adenosine tetraphosphate (AP4). Human NUDT13 activity is inferred from Nudt13 activity in Arabidopsis thaliana (Olejnik et al. 2007). Diadenosine polyphosphates play a role in the cardiovascular system with potential involvement in mediating the pathophysiological effects associated with platelet activation during myocardial ischaemia.

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
pyrophosphatase activity of NUDT13 [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created