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Envoplakin binds periplakin
Stable Identifier
R-HSA-6810843
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Keratinization (Homo sapiens)
Formation of the cornified envelope (Homo sapiens)
Envoplakin binds periplakin (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Envoplakin (EVPL) is insoluble under physiological conditions but soluble as a heterodimer with periplakin (PPL) (Kalinin et al. 2004). The heterodimers provide a firm but flexible structures (Al-Jassar et al. 2013). EVPL and PPL deposition and crosslinking are amongst the earliest events of cornification (Kalinin et al. 2002, Candi et al. 2005). They partially colocalize with desmosomal proteins and keratin intermediate filaments (Ruhrberg et al. 1996, DiColandrea et al. 2000), linking the cornified envelope to desmosomes and keratin filaments (Ruhrberg et al. 1996, 1997). PPL also associates with cortical actin at the interdesmosomal plasma membrane (DiColandrea et al. 2000, Groot et al. 2004).
Literature References
PubMed ID
Title
Journal
Year
15033990
Co-assembly of envoplakin and periplakin into oligomers and Ca(2+)-dependent vesicle binding: implications for cornified cell envelope formation in stratified squamous epithelia
Idler, WW
,
Steven, AC
,
Kalinin, AE
,
Steinert, PM
,
Bowers, B
,
Marekov, LN
,
McPhie, P
J. Biol. Chem.
2004
Participants
Input
EVPL [cytosol]
(Homo sapiens)
PPL [cytosol]
(Homo sapiens)
Output
EVPL:PPL [cytosol]
(Homo sapiens)
Participates
as an event of
Formation of the cornified envelope (Homo sapiens)
Orthologous Events
Envoplakin binds periplakin (Bos taurus)
Envoplakin binds periplakin (Canis familiaris)
Envoplakin binds periplakin (Gallus gallus)
Envoplakin binds periplakin (Mus musculus)
Envoplakin binds periplakin (Rattus norvegicus)
Envoplakin binds periplakin (Sus scrofa)
Envoplakin binds periplakin (Xenopus tropicalis)
Authored
Jupe, S (2016-03-10)
Reviewed
Blumenberg, M (2016-08-12)
Created
Jupe, S (2015-11-19)
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