Envoplakin binds periplakin

Stable Identifier
R-HSA-6810843
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Envoplakin (EVPL) is insoluble under physiological conditions but soluble as a heterodimer with periplakin (PPL) (Kalinin et al. 2004). The heterodimers provide a firm but flexible structures (Al-Jassar et al. 2013). EVPL and PPL deposition and crosslinking are amongst the earliest events of cornification (Kalinin et al. 2002, Candi et al. 2005). They partially colocalize with desmosomal proteins and keratin intermediate filaments (Ruhrberg et al. 1996, DiColandrea et al. 2000), linking the cornified envelope to desmosomes and keratin filaments (Ruhrberg et al. 1996, 1997). PPL also associates with cortical actin at the interdesmosomal plasma membrane (DiColandrea et al. 2000, Groot et al. 2004).

Literature References
PubMed ID Title Journal Year
15033990 Co-assembly of envoplakin and periplakin into oligomers and Ca(2+)-dependent vesicle binding: implications for cornified cell envelope formation in stratified squamous epithelia

Kalinin, AE, Idler, WW, Marekov, LN, McPhie, P, Bowers, B, Steinert, PM, Steven, AC

J. Biol. Chem. 2004
Participants
Participant Of
Orthologous Events
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Reviewed