Reactome | PPL [cytosol]

PPL [cytosol]

Stable Identifier

R-HSA-6810850

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Periplakin, PEPL_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9Y3Q8 T22D4

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External Reference Information

External Reference

UniProt:O60437 PPL

Gene Names

PPL, KIAA0568

Chain

chain:1-1756

Reference Genes

BioGPS Gene:5493 PPL

COSMIC (genes):PPL PPL

CTD Gene:5493 PPL

dbSNP Gene:5493 PPL

ENSEMBL:ENSG00000118898 PPL

HGNC:9273 PPL

Monarch:5493 PPL

NCBI Gene:5493 PPL

OMIM:602871 PPL

UCSC:O60437 PPL

Reference Transcript

RefSeq:NM_002705.4 PPL

Other Identifiers

11722428_a_at

11722429_s_at

11722430_at

11750591_a_at

16823666

203407_PM_at

203407_at

3678463

3678464

3678465

3678466

3678467

3678468

3678469

3678470

3678471

3678472

3678474

3678475

3678476

3678477

3678478

3678479

3678480

3678481

3678482

3678483

3678484

3678485

3678486

3678487

3678488

3678490

3678491

3678492

3678493

3678494

3678496

3678497

3678508

3678509

36890_at

5493

69526_at

7999253

A_23_P106906

GE54042

GO:0001533

GO:0005198

GO:0005200

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005882

GO:0005886

GO:0007010

GO:0009612

GO:0016020

GO:0030057

GO:0031424

GO:0042060

GO:0043226

GO:0045104

GO:0045296

GO:0070062

GO:0070161

HMNXSV003049489

ILMN_1806030

PH_hs_0022926

TC16000838.hg

g4505992_3p_at

Participates

as a component of

as an input of

Other forms of this molecule

PPL [cornified envelope]

Inferred To

PPL [cytosol] (Bos taurus)

PPL [cytosol] (Canis familiaris)

PPL [cytosol] (Gallus gallus)

PPL [cytosol] (Sus scrofa)

Ppl [cytosol] (Mus musculus)

Ppl [cytosol] (Rattus norvegicus)

ppl [cytosol] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000118898

ENSEMBL

ENSP00000340510, ENST00000345988

HPA

ENSG00000118898-PPL

PRO

O60437

Pharos - Targets

O60437

GlyGen

O60437

PDB

4Q28

Interactors (46)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.718	6
UniProt:P13196 ALAS1	2	PXLP-ALAS1 [mitochondrial matrix] (R-HSA-1022086) ALAS1 [mitochondrial matrix] (R-HSA-189438)	0.718	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	8
UniProt:Q15311 RALBP1	1	RALBP1 [cytosol] (R-HSA-195194)	0.666	5
UniProt:O76027 ANXA9			0.664	7
UniProt:O00481 BTN3A1	1	BTN3A1 [plasma membrane] (R-HSA-8851049)	0.625	6
UniProt:Q6A163 KRT39	1	KRT39 [cytosol] (R-HSA-6809592)	0.601	4
UniProt:O00481-2 BTN3A1			0.591	5
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.573	2
UniProt:Q9H9F9 ACTR5	1	ACTR5 [nucleoplasm] (R-HSA-5688913)	0.556	3
UniProt:Q5SZD1 CF141			0.556	3
UniProt:Q8NBB4 ZSCA1			0.556	3
UniProt:Q7Z3Z0 KRT25	1	KRT25 [cytosol] (R-HSA-6809613)	0.556	3
UniProt:Q13422-7 IKZF1			0.556	3
UniProt:O43865 AHCYL1	1	AHCYL1 [endoplasmic reticulum membrane] (R-HSA-5215973)	0.556	3
UniProt:P49910 ZN165			0.556	3
UniProt:Q8NBB4-2 ZSCAN1			0.556	3
UniProt:Q4G0X4 KCD21			0.556	3
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.556	3
UniProt:Q9HCK0 ZBT26			0.556	3
UniProt:Q96QF0 RAB3IP	1	RAB3IP [cytosol] (R-HSA-5617610)	0.556	3
UniProt:Q96BW1 UPP			0.556	3
UniProt:O14978 ZNF263	1	ZNF263 [nucleoplasm] (R-HSA-1027393)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:P17661 DES	1	DES [cytosol] (R-HSA-390570)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q9Y448 SKAP			0.556	3
UniProt:Q8IYX8-2 CEP57L1			0.556	3
UniProt:O14771 ZNF213	1	ZNF213 [nucleoplasm] (R-HSA-1027351)	0.556	3
UniProt:Q96QF0-7 RAB3IP			0.556	3
UniProt:Q9Y3Q8 T22D4			0.556	3
UniProt:Q9BYU1 PBX4			0.556	3
UniProt:Q6IQ23-2 PLEKHA7			0.556	3
UniProt:Q5T447 HECTD3	1	HECTD3 [cytosol] (R-HSA-975991)	0.556	3
UniProt:Q8WVV4-1 POF1B			0.556	3
UniProt:Q6S9Z5 ZN474			0.556	3
UniProt:Q13084 MRPL28	1	MRPL28 [mitochondrial inner membrane] (R-HSA-5368246)	0.556	3
UniProt:Q9H4T2 ZSC16			0.556	3
UniProt:P02794 FTH1	5	FTH1 [cytosol] (R-HSA-434212) FTH1 [tertiary granule lumen] (R-HSA-6801508) FTH1 [extracellular region] (R-HSA-2187212) FTH1 [ficolin-1-rich granule lumen] (R-HSA-6801531) FTH1 [endocytic vesicle lumen] (R-HSA-2299670)	0.527	2
UniProt:Q9Y324 FCF1	1	FCF1 [nucleoplasm] (R-HSA-6790672)	0.527	2
UniProt:Q9HAW8 UGT1A10	1	UGT1A10 [endoplasmic reticulum membrane] (R-HSA-8933307)	0.527	2
UniProt:Q9BX46 RBM24			0.527	2
UniProt:Q9H845 ACAD9	1	ACAD9 [mitochondrial inner membrane] (R-HSA-5689049)	0.527	2
UniProt:Q9NU19 TB22B			0.527	2
UniProt:Q14943 KIR3DS1	1	KIR3DS1 [plasma membrane] (R-HSA-2159806)	0.527	2
UniProt:Q8N878 FRMD1			0.527	2

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