Reactome | SPRR2F [cytosol]

SPRR2F [cytosol]

Stable Identifier

R-HSA-6810858

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Small proline-rich protein 2F, SPR2F_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Keratinization (Homo sapiens)
  - Formation of the cornified envelope (Homo sapiens)
    - CASP14 cleaves filaggrin (Homo sapiens)
      - Late cornified envelope [plasma membrane] (Homo sapiens)
        
        Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        SPRs [cytosol] (Homo sapiens)
        
        SPRR2F [cytosol] (Homo sapiens)
      - Mature cornified envelope [plasma membrane] (Homo sapiens)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
        
        No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
        
        SPRs [cytosol] (Homo sapiens)
        
        SPRR2F [cytosol] (Homo sapiens)
    - CDSN binds the cornified envelope (Homo sapiens)
      - Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        SPRs [cytosol] (Homo sapiens)
        
        SPRR2F [cytosol] (Homo sapiens)
      - Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        SPRs [cytosol] (Homo sapiens)
        
        SPRR2F [cytosol] (Homo sapiens)
    - Lamellar bodies bind the early cornified envelope (Homo sapiens)
      - Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        SPRs [cytosol] (Homo sapiens)
        
        SPRR2F [cytosol] (Homo sapiens)
      - Early cornified envelope [plasma membrane] (Homo sapiens)
        
        SPRs [cytosol] (Homo sapiens)
        
        SPRR2F [cytosol] (Homo sapiens)
    - Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)
      - Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        SPRs [cytosol] (Homo sapiens)
        
        SPRR2F [cytosol] (Homo sapiens)
      - Late cornified envelope [plasma membrane] (Homo sapiens)
        
        Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        SPRs [cytosol] (Homo sapiens)
        
        SPRR2F [cytosol] (Homo sapiens)
    - Plasma membrane resorption (Homo sapiens)
      - Mature cornified envelope [plasma membrane] (Homo sapiens)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
        
        No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
        
        SPRs [cytosol] (Homo sapiens)
        
        SPRR2F [cytosol] (Homo sapiens)
    - Reinforcement of the Cornified Envelope (Homo sapiens)
      - Early cornified envelope [plasma membrane] (Homo sapiens)
        
        SPRs [cytosol] (Homo sapiens)
        
        SPRR2F [cytosol] (Homo sapiens)
      - SPRs [cytosol] (Homo sapiens)
        
        SPRR2F [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96RM1 SPRR2F

Gene Names

SPRR2F

Chain

chain:1-72

Reference Genes

BioGPS Gene:6705 SPRR2F

COSMIC (genes):SPRR2F SPRR2F

CTD Gene:6705 SPRR2F

dbSNP Gene:6705 SPRR2F

ENSEMBL:ENSG00000244094 SPRR2F

ENSEMBL_homo_sapiens_GENE:ENSG00000244094.2 SPRR2F

HGNC:11266 SPRR2F

KEGG Gene (Homo sapiens):6705 SPRR2F

Monarch:6705 SPRR2F

NCBI Gene:6705 SPRR2F

OMIM:617589 SPRR2F

UCSC:Q96RM1 SPRR2F

Reference Transcript

Other Identifiers

11733956_at

11733957_x_at

16693375

2435851

2435852

2435861

2435866

2435867

2435871

2435872

2435876

2435877

55581_at

6705

8180384

A_33_P3274811

GO:0001533

GO:0005737

GO:0005829

GO:0005886

GO:0008544

GO:0030154

GO:0030216

GO:0031424

GO:0048856

L05188_f_at

TC01006376.hg

Participates

as a member of

SPRs [cytosol] (Homo sapiens)

Other forms of this molecule

SPRR2F [cornified envelope]

Cross References

RefSeq

NP_001014450.1, XP_016857665.1

OpenTargets

ENSG00000244094

HPA

ENSG00000244094-SPRR2F

GeneCards

Q96RM1

Ensembl

ENSG00000244094, ENST00000468739, ENSP00000418193

PRO

Q96RM1

Pharos - Targets

Q96RM1