TGM1 and involucrin bind the plasma membrane

Stable Identifier
R-HSA-6810899
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Transglutaminase-1 (TGM1) and involucrin (IVL) are expressed shortly after envoplakin and periplakin. TGM1 associates with the plasma membrane via C14-16 fatty-acid adducts on its C-terminus (Steinert et al. 1996). IVL deposition precedes that of most other cornified envelope proteins (Nemes & Steinert 1999). It can bind the plasma membrane in a calcium and phosphatidyl-serine dependent manner, where it becomes a substrate for membrane-bound TGM1 and TGM5 (Nemes et al. 1999, Candi et al. 2001).

Literature References
PubMed ID Title Journal Year
8824274 The transglutaminase 1 enzyme is variably acylated by myristate and palmitate during differentiation in epidermal keratinocytes

Steinert, PM, Kim, SY, Chung, SI, Marekov, LN

J. Biol. Chem. 1996
10231017 Bricks and mortar of the epidermal barrier

Nemes, Z, Steinert, PM

Exp. Mol. Med. 1999
10196183 Involucrin cross-linking by transglutaminase 1. Binding to membranes directs residue specificity

Nemes, Z, Marekov, LN, Steinert, PM

J. Biol. Chem. 1999
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