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Lamellar bodies bind the early cornified envelope
Stable Identifier
R-HSA-6810937
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Keratinization (Homo sapiens)
Formation of the cornified envelope (Homo sapiens)
Lamellar bodies bind the early cornified envelope (Homo sapiens)
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Lamellar bodies (LBs) ) are lipid-rich organelles produced by keratinocytes and secreted to form an impermeable water barrier (Feingold & Elias 2014). The lipids in LBs contain phospholipids, glucosylceramides, sphingomyelin and cholesterol (Feingold 2007). These lipids, some of which are keratinization specific, are synthesized and accumulate in the trans Golgi apparatus, budding off as LBs that accumulate in the granular layer (Wertz & van den Bergh 1998). ). LB lipids also organize into characteristic intercellular lamellae (Kalinin et al. 2002). LBs fuse with the plasma membrane (Schmitz & Muller 1991, Chattopadhyay et al. 2003) delivering lipids which become ester-linked to involucrin and probably other cornified envelope proteins by TG1 (Nemes et al. 1991) and possibly TG5 (Candi et al. 2005), forming a monomolecular layer termed the lipid envelope. Eventually these lipids replace the plasma membrane lipid bilayer, which is reabsorbed. Extracellularly, the LB lipids are further metabolized to have a unique composition and are 50% ceramides, 25% cholesterol, and 15% free fatty acids (Feingold 2007).
Literature References
PubMed ID
Title
Journal
Year
12902340
Fusion of lamellar body with plasma membrane is driven by the dual action of annexin II tetramer and arachidonic acid
Wang, P
,
Liu, L
,
Chattopadhyay, S
,
Abonyo, B
,
Cross, NL
,
Sun, P
J. Biol. Chem.
2003
Participants
Input
Early cornified envelope [plasma membrane]
(Homo sapiens)
Lamellar body [cytosol]
Output
Cornified envelope [plasma membrane]
(Homo sapiens)
Participates
as an event of
Formation of the cornified envelope (Homo sapiens)
Orthologous Events
Lamellar bodies bind the early cornified envelope (Bos taurus)
Lamellar bodies bind the early cornified envelope (Canis familiaris)
Lamellar bodies bind the early cornified envelope (Mus musculus)
Lamellar bodies bind the early cornified envelope (Rattus norvegicus)
Authored
Jupe, S (2016-03-10)
Reviewed
Blumenberg, M (2016-08-12)
Created
Jupe, S (2015-11-19)
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