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VPS52 [trans-Golgi network membrane]
Stable Identifier
R-HSA-6811029
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
trans-Golgi network membrane
Synonyms
Vacuolar protein sorting-associated protein 52 homolog, SAC2 suppressor of actin mutations 2-like protein
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Retrograde transport at the Trans-Golgi-Network (Homo sapiens)
Fusion of early-endosome derived vesicles at the TGN (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS52 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS52 [trans-Golgi network membrane] (Homo sapiens)
Fusion of late-endosome derived vesicles at the TGN (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS52 [trans-Golgi network membrane] (Homo sapiens)
RAB9:GTP:p-RABEPK:VAMP3:STX16:STX10:VTI1A:GARP complex:GCC2 dimer:late-endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS52 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS52 [trans-Golgi network membrane] (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS52 [trans-Golgi network membrane] (Homo sapiens)
Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS52 [trans-Golgi network membrane] (Homo sapiens)
RAB9:GTP:p-RABEPK:VAMP3:STX16:STX10:VTI1A:GARP complex:GCC2 dimer:late-endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
GARP complex [trans-Golgi network membrane] (Homo sapiens)
VPS52 [trans-Golgi network membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N1B4 VPS52
Gene Names
VPS52, SACM2L
Chain
initiator methionine:1, chain:2-723
Reference Genes
BioGPS Gene:6293 VPS52
COSMIC (genes):VPS52 VPS52
CTD Gene:6293 VPS52
dbSNP Gene:6293 VPS52
ENSEMBL:ENSG00000206286 VPS52
ENSEMBL:ENSG00000223501 VPS52
ENSEMBL:ENSG00000224455 VPS52
ENSEMBL:ENSG00000225590 VPS52
ENSEMBL:ENSG00000228425 VPS52
ENSEMBL:ENSG00000236014 VPS52
HGNC:10518 VPS52
KEGG Gene (Homo sapiens):6293 VPS52
Monarch:6293 VPS52
NCBI Gene:6293 VPS52
OMIM:603443 VPS52
UCSC:Q8N1B4 VPS52
Reference Transcript
RefSeq:NM_001289175.1 VPS52
RefSeq:NM_022553.5 VPS52
RefSeq:XM_017011178.1 VPS52
RefSeq:NM_001289176.1 VPS52
Other Identifiers
0003840112
0003840546
11717079_a_at
11717080_x_at
11717081_a_at
11746006_a_at
11746049_a_at
11746050_x_at
17018130
17029942
17032627
17034947
17037427
17040137
17042619
214585_s_at
2950516
2950517
2950518
2950519
2950520
2950521
2950523
2950524
2950527
2950529
2950530
2950533
2950535
2950536
2950539
2950541
2950542
2950543
2950544
2950545
2950546
2950548
2950549
2950550
2950551
2950555
2950556
2950557
32658_at
42667
48128
6293
8125649
8178917
8180123
A0A0G2JIG2
A_23_P70583
AAH32108
AAH40114
AK222867
AK297935
AL031228
AL390171
AL645940
BAD96587
BAG60251
BC032108
BC040114
BX248408
CAB99099
CAI95618
CAI95619
CCDS4770
CH471081
CR759786
CR759817
CR762434
E9PI03
EAX03688
ENSG00000206286
ENSG00000223501
ENSG00000224455
ENSG00000225590
ENSG00000228425
ENSG00000236014
ENSP00000372697
ENSP00000390831
ENSP00000391197
ENSP00000404016
ENSP00000406988
ENSP00000409952
ENST00000383210
ENST00000428608
ENST00000441058
ENST00000443860
ENST00000445902
ENST00000445902.2
ENST00000448042
EntrezGene:6293
EntrezGene:VPS52
GE55890
GO:0000938
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005768
GO:0005794
GO:0005829
GO:0006810
GO:0006896
GO:0007034
GO:0007041
GO:0008150
GO:0009790
GO:0010008
GO:0010668
GO:0015031
GO:0016020
GO:0016192
GO:0017137
GO:0019899
GO:0019905
GO:0030154
GO:0031410
GO:0032456
GO:0032588
GO:0032991
GO:0042147
GO:0043226
GO:0048471
GO:0048611
GO:0048856
GO:0055037
GO:1990745
HGNC:10518
HPA042667
HPA048128
Hs.169407.1.A2_3p_a_at
ILMN_1666632
IPR007258
MIM:603443
NM_001289174
NM_001289175
NM_001289176
NM_022553
NP_001276103
NP_001276104
NP_001276105
NP_072047
PF04129
PH_hs_0020146
Q4VXZ2
TC06001581.hg
TC6_cox_hap2000205.hg
TC6_dbb_hap3000191.hg
TC6_mann_hap4000173.hg
TC6_mcf_hap5000180.hg
TC6_qbl_hap6000193.hg
TC6_ssto_hap7000174.hg
UPI000006E468
VPS52
VPS52-201
VPS52-212
VPS52-229
VPS52-240
VPS52-251
VPS52-262
XM_011514797
XM_011514798
XM_011514799
XM_017011177
XM_017011178
XM_024446519
XP_011513099
XP_011513100
XP_011513101
XP_016866666
XP_016866667
XP_024302287
Participant Of
hasComponent
GARP complex [trans-Golgi network membrane]
Inferred To
VPS52 [trans-Golgi network membrane] (Bos taurus)
VPS52 [trans-Golgi network membrane] (Caenorhabditis elegans)
VPS52 [trans-Golgi network membrane] (Canis familiaris)
VPS52 [trans-Golgi network membrane] (Danio rerio)
VPS52 [trans-Golgi network membrane] (Dictyostelium discoideum)
VPS52 [trans-Golgi network membrane] (Drosophila melanogaster)
VPS52 [trans-Golgi network membrane] (Mus musculus)
VPS52 [trans-Golgi network membrane] (Rattus norvegicus)
VPS52 [trans-Golgi network membrane] (Saccharomyces cerevisiae)
VPS52 [trans-Golgi network membrane] (Schizosaccharomyces pombe)
VPS52 [trans-Golgi network membrane] (Sus scrofa)
VPS52 [trans-Golgi network membrane] (Xenopus tropicalis)
Ghost homologue of VPS52 [trans-Golgi network membrane] (Gallus gallus)
Cross References
RefSeq
XP_016866667.1
,
NP_001276104.1
,
NP_001276105.1
,
NP_072047.4
OpenTargets
ENSG00000223501
GeneCards
Q8N1B4
PRO
Q8N1B4
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40222 TXLNA
1
TXLNA [cytosol]
(R-HSA-449124)
0.696
5
UniProt:O75604 USP2
2
USP2 [nucleoplasm]
(R-HSA-5689946)
USP2 [cytosol]
(R-HSA-5212661)
0.696
5
UniProt:Q9Y4K3 TRAF6
8
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [plasma membrane]
(R-HSA-936955)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
0.696
5
UniProt:Q99757 TXN2
3
HC-TXN2 [mitochondrial matrix]
(R-HSA-9035482)
TXN2 [mitochondrial matrix]
(R-HSA-3323048)
2xHC-TXN2 [mitochondrial matrix]
(R-HSA-3323059)
0.696
5
UniProt:Q9H4P4 RNF41
1
RNF41 [cytosol]
(R-HSA-975977)
0.696
5
UniProt:Q15561 TEAD4
1
TEAD4 [nucleoplasm]
(R-HSA-2032780)
0.556
3
UniProt:O14964 HGS
2
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
HGS [cytosol]
(R-HSA-182954)
0.556
3
UniProt:P46087 NOP2
1
NOP2 [nucleoplasm]
(R-HSA-6790922)
0.556
3
UniProt:P54646 PRKAA2
4
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.556
3
UniProt:Q9NVH1 DNAJC11
1
DNAJC11 [mitochondrial outer membrane]
(R-HSA-8949572)
0.488
2
UniProt:Q92917 GPKOW
1
GPKOW [nucleoplasm]
(R-HSA-8850839)
0.488
2
UniProt:Q86TI0 TBC1D1
2
p-S237-TBC1D1 [cytosol]
(R-HSA-1454673)
TBC1D1 [cytoplasmic vesicle membrane]
(R-HSA-1454718)
0.488
2
UniProt:Q9HAQ2 KIF9
1
KIF9 [cytosol]
(R-HSA-984616)
0.488
2
UniProt:Q13895 BYSL
2
BYSL [cytosol]
(R-HSA-6791518)
BYSL [nucleoplasm]
(R-HSA-6791526)
0.488
2
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