Reactome | VPS52 [trans-Golgi network membrane]

VPS52 [trans-Golgi network membrane]

Stable Identifier

R-HSA-6811029

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

trans-Golgi network membrane

Synonyms

Vacuolar protein sorting-associated protein 52 homolog, SAC2 suppressor of actin mutations 2-like protein

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q8N1B4 VPS52

Gene Names

VPS52, SACM2L

Chain

initiator methionine:, chain:2-723

Reference Genes

BioGPS Gene:6293 VPS52

COSMIC (genes):VPS52 VPS52

CTD Gene:6293 VPS52

dbSNP Gene:6293 VPS52

ENSEMBL:ENSG00000223501 VPS52

HGNC:10518 VPS52

Monarch:6293 VPS52

NCBI Gene:6293 VPS52

OMIM:603443 VPS52

UCSC:Q8N1B4 VPS52

Reference Transcript

Other Identifiers

11717079_a_at

11717080_x_at

11717081_a_at

11746006_a_at

11746049_a_at

11746050_x_at

17018130

17029942

17032627

17034947

17037427

17040137

17042619

214585_PM_s_at

214585_s_at

2950514

2950516

2950517

2950518

2950519

2950520

2950521

2950522

2950523

2950524

2950527

2950528

2950529

2950530

2950531

2950532

2950533

2950534

2950535

2950536

2950537

2950538

2950539

2950540

2950541

2950542

2950543

2950544

2950545

2950546

2950547

2950548

2950549

2950550

2950551

2950552

2950553

2950554

2950555

2950556

2950557

2950558

32658_at

6293

8125649

8178917

8180123

A_23_P70583

A_33_P3294886

GE553745

GE55890

GO:0000938

GO:0005515

GO:0005768

GO:0005794

GO:0005829

GO:0006605

GO:0006896

GO:0007041

GO:0010008

GO:0010668

GO:0015031

GO:0016020

GO:0016192

GO:0019905

GO:0030154

GO:0031410

GO:0032456

GO:0032588

GO:0042147

GO:0043226

GO:0048471

GO:0048611

GO:0048856

GO:0055037

GO:0090119

GO:0098793

GO:0098794

GO:1990745

HMNXSV003003855

HMNXSV003045901

HMNXSV003058089

Hs.169407.1.A2_3p_a_at

ILMN_1666632

PH_hs_0020146

TC06001581.hg

TC6_cox_hap2000205.hg

TC6_dbb_hap3000191.hg

TC6_mann_hap4000173.hg

TC6_mcf_hap5000180.hg

TC6_qbl_hap6000193.hg

TC6_ssto_hap7000174.hg

Participates

as a component of

GARP complex [trans-Golgi network membrane] (Homo sapiens)

Inferred To

vps52 [trans-Golgi network membrane] (Schizosaccharomyces pombe)

VPS52 [trans-Golgi network membrane] (Bos taurus)

VPS52 [trans-Golgi network membrane] (Canis familiaris)

VPS52 [trans-Golgi network membrane] (Saccharomyces cerevisiae)

VPS52 [trans-Golgi network membrane] (Sus scrofa)

Vps52 [trans-Golgi network membrane] (Drosophila melanogaster)

Vps52 [trans-Golgi network membrane] (Mus musculus)

Vps52 [trans-Golgi network membrane] (Rattus norvegicus)

Ghost homologue of VPS52 [trans-Golgi network membrane] (Danio rerio)

Ghost homologue of VPS52 [trans-Golgi network membrane] (Gallus gallus)

vps-52 [trans-Golgi network membrane] (Caenorhabditis elegans)

vps52B [trans-Golgi network membrane] (Dictyostelium discoideum)

Cross References

OpenTargets

ENSG00000223501

ENSEMBL

ENSP00000409952, ENST00000441058, ENST00000443860, ENSP00000391197, ENST00000428608, ENSP00000406988, ENSP00000404016, ENSP00000390831, ENSP00000372697, ENST00000383210, ENST00000445902, ENST00000448042

HPA

ENSG00000223501-VPS52

PRO

Q8N1B4

Pharos - Targets

Q8N1B4

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H4P4 RNF41	1	RNF41 [cytosol] (R-HSA-975977)	0.782	7
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.782	7
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.718	6
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.718	6
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.718	6
UniProt:P55081 MFAP1	1	MFAP1 [nucleoplasm] (R-HSA-2396419)	0.718	6
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	3
UniProt:Q9HAQ2 KIF9	1	KIF9 [cytosol] (R-HSA-984616)	0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:P46087 NOP2	1	NOP2 [nucleoplasm] (R-HSA-6790922)	0.556	3
UniProt:Q96NC0 ZMAT2	1	ZMAT2 [nucleoplasm] (R-HSA-9770248)	0.556	3
UniProt:Q15561 TEAD4	1	TEAD4 [nucleoplasm] (R-HSA-2032780)	0.556	3
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.556	3
UniProt:Q9NVH1 DNAJC11	1	DNAJC11 [mitochondrial outer membrane] (R-HSA-8949572)	0.556	3
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.556	3
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3
UniProt:Q86TI0 TBC1D1	2	TBC1D1 [cytoplasmic vesicle membrane] (R-HSA-1454718) p-S237-TBC1D1 [cytosol] (R-HSA-1454673)	0.556	3
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.527	2

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