Reactome | VPS52 [trans-Golgi network membrane]

VPS52 [trans-Golgi network membrane]

Stable Identifier

R-HSA-6811029

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

trans-Golgi network membrane

Synonyms

Vacuolar protein sorting-associated protein 52 homolog, SAC2 suppressor of actin mutations 2-like protein

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q8N1B4 VPS52

Gene Names

VPS52, SACM2L

Chain

initiator methionine:1, chain:2-723

Reference Genes

BioGPS Gene:6293 VPS52

COSMIC (genes):VPS52 VPS52

CTD Gene:6293 VPS52

dbSNP Gene:6293 VPS52

ENSEMBL:ENSG00000206286.11 VPS52

ENSEMBL:ENSG00000223501 VPS52

ENSEMBL:ENSG00000223501.9 VPS52

ENSEMBL:ENSG00000224455.9 VPS52

ENSEMBL:ENSG00000225590.9 VPS52

ENSEMBL:ENSG00000228425.9 VPS52

ENSEMBL:ENSG00000236014.10 VPS52

HGNC:10518 VPS52

KEGG Gene (Homo sapiens):6293 VPS52

Monarch:6293 VPS52

NCBI Gene:6293 VPS52

OMIM:603443 VPS52

UCSC:Q8N1B4 VPS52

Reference Transcript

Other Identifiers

0003840112

0003840546

11717079_a_at

11717080_x_at

11717081_a_at

11746006_a_at

11746049_a_at

11746050_x_at

17018130

17029942

17032627

17034947

17037427

17040137

17042619

214585_PM_s_at

214585_s_at

2950516

2950517

2950518

2950519

2950520

2950521

2950523

2950524

2950527

2950529

2950530

2950533

2950535

2950536

2950539

2950541

2950542

2950543

2950544

2950545

2950546

2950548

2950549

2950550

2950551

2950555

2950556

2950557

32658_at

6293

8125649

8178917

8180123

A_23_P70583

GE55890

GO:0000938

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005768

GO:0005794

GO:0005829

GO:0006896

GO:0007041

GO:0008150

GO:0010008

GO:0010668

GO:0015031

GO:0016020

GO:0016192

GO:0019905

GO:0030154

GO:0031410

GO:0032456

GO:0032588

GO:0032991

GO:0042147

GO:0043226

GO:0048471

GO:0048611

GO:0048856

GO:0055037

GO:1990745

HMNXSV003045901

HMNXSV003058089

Hs.169407.1.A2_3p_a_at

ILMN_1666632

PH_hs_0020146

TC06001581.hg

TC6_cox_hap2000205.hg

TC6_dbb_hap3000191.hg

TC6_mann_hap4000173.hg

TC6_mcf_hap5000180.hg

TC6_qbl_hap6000193.hg

TC6_ssto_hap7000174.hg

Participates

as a component of

GARP complex [trans-Golgi network membrane] (Homo sapiens)

Inferred To

vps52 [trans-Golgi network membrane] (Schizosaccharomyces pombe)

vps52 [trans-Golgi network membrane] (Xenopus tropicalis)

VPS52 [trans-Golgi network membrane] (Bos taurus)

VPS52 [trans-Golgi network membrane] (Canis familiaris)

VPS52 [trans-Golgi network membrane] (Danio rerio)

VPS52 [trans-Golgi network membrane] (Dictyostelium discoideum)

VPS52 [trans-Golgi network membrane] (Saccharomyces cerevisiae)

VPS52 [trans-Golgi network membrane] (Sus scrofa)

Vps52 [trans-Golgi network membrane] (Drosophila melanogaster)

Vps52 [trans-Golgi network membrane] (Mus musculus)

Vps52 [trans-Golgi network membrane] (Rattus norvegicus)

Ghost homologue of VPS52 [trans-Golgi network membrane] (Gallus gallus)

vps-52 [trans-Golgi network membrane] (Caenorhabditis elegans)

Cross References

RefSeq

XP_016866667.1, NP_072047.4, NP_001276104.1, NP_001276105.1

OpenTargets

ENSG00000223501

HPA

ENSG00000223501-VPS52

GeneCards

Q8N1B4

Ensembl

ENSG00000225590, ENSP00000391197, ENSP00000404016, ENST00000445902, ENSP00000406988, ENSG00000206286, ENST00000383210, ENSP00000372697, ENST00000443860, ENSG00000224455, ENSG00000228425, ENSG00000236014, ENSP00000409952, ENST00000441058, ENST00000448042, ENSG00000223501, ENST00000428608, ENSP00000390831

PRO

Q8N1B4

Pharos - Targets

Q8N1B4

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.718	6
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.718	6
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.718	6
UniProt:Q9H4P4 RNF41	1	RNF41 [cytosol] (R-HSA-975977)	0.718	6
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227)	0.718	6
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.556	3
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:Q9NVH1 DNAJC11	1	DNAJC11 [mitochondrial outer membrane] (R-HSA-8949572)	0.556	3
UniProt:P46087 NOP2	1	NOP2 [nucleoplasm] (R-HSA-6790922)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	3
UniProt:Q86TI0 TBC1D1	2	TBC1D1 [cytoplasmic vesicle membrane] (R-HSA-1454718) p-S237-TBC1D1 [cytosol] (R-HSA-1454673)	0.556	3
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3
UniProt:Q9HAQ2 KIF9	1	KIF9 [cytosol] (R-HSA-984616)	0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:Q15561 TEAD4	1	TEAD4 [nucleoplasm] (R-HSA-2032780)	0.556	3

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