Reactome | VPS52 [trans-Golgi network membrane]

VPS52 [trans-Golgi network membrane]

Stable Identifier

R-HSA-6811029

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

trans-Golgi network membrane

Synonyms

Vacuolar protein sorting-associated protein 52 homolog, SAC2 suppressor of actin mutations 2-like protein

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8N1B4 VPS52

Gene Names

VPS52, SACM2L

Chain

initiator methionine:1, chain:2-723

Reference Genes

BioGPS Gene:6293 VPS52

COSMIC (genes):VPS52 VPS52

CTD Gene:6293 VPS52

dbSNP Gene:6293 VPS52

ENSEMBL:ENSG00000206286 VPS52

ENSEMBL:ENSG00000223501 VPS52

ENSEMBL:ENSG00000224455 VPS52

ENSEMBL:ENSG00000225590 VPS52

ENSEMBL:ENSG00000228425 VPS52

ENSEMBL:ENSG00000236014 VPS52

HGNC:10518 VPS52

KEGG Gene (Homo sapiens):6293 VPS52

Monarch:6293 VPS52

NCBI Gene:6293 VPS52

OMIM:603443 VPS52

UCSC:Q8N1B4 VPS52

Reference Transcript

Other Identifiers

0003840112

0003840546

11717079_a_at

11717080_x_at

11717081_a_at

11746006_a_at

11746049_a_at

11746050_x_at

17018130

17029942

17032627

17034947

17037427

17040137

17042619

214585_s_at

2950516

2950517

2950518

2950519

2950520

2950521

2950523

2950524

2950527

2950529

2950530

2950533

2950535

2950536

2950539

2950541

2950542

2950543

2950544

2950545

2950546

2950548

2950549

2950550

2950551

2950555

2950556

2950557

32658_at

42667

48128

6293

8125649

8178917

8180123

A0A0G2JIG2

A_23_P70583

AAH32108

AAH40114

AK222867

AK297935

AL031228

AL390171

AL645940

BAD96587

BAG60251

BC032108

BC040114

BX248408

CAB99099

CAI95618

CAI95619

CCDS4770

CH471081

CR759786

CR759817

CR762434

E9PI03

EAX03688

ENSG00000206286

ENSG00000223501

ENSG00000224455

ENSG00000225590

ENSG00000228425

ENSG00000236014

ENSP00000372697

ENSP00000390831

ENSP00000391197

ENSP00000404016

ENSP00000406988

ENSP00000409952

ENST00000383210

ENST00000428608

ENST00000441058

ENST00000443860

ENST00000445902

ENST00000445902.2

ENST00000448042

EntrezGene:6293

EntrezGene:VPS52

GE55890

GO:0000938

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005768

GO:0005794

GO:0005829

GO:0006810

GO:0006896

GO:0007034

GO:0007041

GO:0008150

GO:0009790

GO:0010008

GO:0010668

GO:0015031

GO:0016020

GO:0016192

GO:0017137

GO:0019899

GO:0019905

GO:0030154

GO:0031410

GO:0032456

GO:0032588

GO:0032991

GO:0042147

GO:0043226

GO:0048471

GO:0048611

GO:0048856

GO:0055037

GO:1990745

HGNC:10518

HPA042667

HPA048128

Hs.169407.1.A2_3p_a_at

ILMN_1666632

IPR007258

MIM:603443

NM_001289174

NM_001289175

NM_001289176

NM_022553

NP_001276103

NP_001276104

NP_001276105

NP_072047

PF04129

PH_hs_0020146

Q4VXZ2

TC06001581.hg

TC6_cox_hap2000205.hg

TC6_dbb_hap3000191.hg

TC6_mann_hap4000173.hg

TC6_mcf_hap5000180.hg

TC6_qbl_hap6000193.hg

TC6_ssto_hap7000174.hg

UPI000006E468

VPS52

VPS52-201

VPS52-212

VPS52-229

VPS52-240

VPS52-251

VPS52-262

XM_011514797

XM_011514798

XM_011514799

XM_017011177

XM_017011178

XM_024446519

XP_011513099

XP_011513100

XP_011513101

XP_016866666

XP_016866667

XP_024302287

Participant Of

hasComponent

GARP complex [trans-Golgi network membrane]

Inferred To

VPS52 [trans-Golgi network membrane] (Bos taurus)

VPS52 [trans-Golgi network membrane] (Caenorhabditis elegans)

VPS52 [trans-Golgi network membrane] (Canis familiaris)

VPS52 [trans-Golgi network membrane] (Danio rerio)

VPS52 [trans-Golgi network membrane] (Dictyostelium discoideum)

VPS52 [trans-Golgi network membrane] (Drosophila melanogaster)

VPS52 [trans-Golgi network membrane] (Mus musculus)

VPS52 [trans-Golgi network membrane] (Rattus norvegicus)

VPS52 [trans-Golgi network membrane] (Saccharomyces cerevisiae)

VPS52 [trans-Golgi network membrane] (Schizosaccharomyces pombe)

VPS52 [trans-Golgi network membrane] (Sus scrofa)

VPS52 [trans-Golgi network membrane] (Xenopus tropicalis)

Ghost homologue of VPS52 [trans-Golgi network membrane] (Gallus gallus)

Cross References

RefSeq

XP_016866667.1, NP_001276104.1, NP_001276105.1, NP_072047.4

OpenTargets

ENSG00000223501

GeneCards

Q8N1B4

PRO

Q8N1B4

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.696	5
UniProt:O75604 USP2	2	USP2 [nucleoplasm] (R-HSA-5689946) USP2 [cytosol] (R-HSA-5212661)	0.696	5
UniProt:Q9Y4K3 TRAF6	8	K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [plasma membrane] (R-HSA-936955) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.696	5
UniProt:Q99757 TXN2	3	HC-TXN2 [mitochondrial matrix] (R-HSA-9035482) TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.696	5
UniProt:Q9H4P4 RNF41	1	RNF41 [cytosol] (R-HSA-975977)	0.696	5
UniProt:Q15561 TEAD4	1	TEAD4 [nucleoplasm] (R-HSA-2032780)	0.556	3
UniProt:O14964 HGS	2	HGS [phagocytic vesicle lumen] (R-HSA-9635660) HGS [cytosol] (R-HSA-182954)	0.556	3
UniProt:P46087 NOP2	1	NOP2 [nucleoplasm] (R-HSA-6790922)	0.556	3
UniProt:P54646 PRKAA2	4	p-T172-PRKAA2 [cytosol] (R-HSA-200417) PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:Q9NVH1 DNAJC11	1	DNAJC11 [mitochondrial outer membrane] (R-HSA-8949572)	0.488	2
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.488	2
UniProt:Q86TI0 TBC1D1	2	p-S237-TBC1D1 [cytosol] (R-HSA-1454673) TBC1D1 [cytoplasmic vesicle membrane] (R-HSA-1454718)	0.488	2
UniProt:Q9HAQ2 KIF9	1	KIF9 [cytosol] (R-HSA-984616)	0.488	2
UniProt:Q13895 BYSL	2	BYSL [cytosol] (R-HSA-6791518) BYSL [nucleoplasm] (R-HSA-6791526)	0.488	2