Retrograde COPI vesicles bind kinesin and microtubules

Stable Identifier
Reaction [binding]
Homo sapiens
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COPI-mediated retrograde traffic is dependent on microtubules and the plus-end motor kinsesin. Although it is not shown in this reaction, vesicle translocation along the microtubules by kinesin depends on ATP hydrolysis (Lippincott-Scwartz et al, 1995; Stauber et al, 2006; Tomas et al, 2010)

Literature References
PubMed ID Title Journal Year
17113389 A role for kinesin-2 in COPI-dependent recycling between the ER and the Golgi complex

Stauber, T, Simpson, JC, Pepperkok, R, Vernos, I

Curr. Biol. 2006
7844144 Kinesin is the motor for microtubule-mediated Golgi-to-ER membrane traffic

Lippincott-Schwartz, J, Cole, NB, Marotta, A, Conrad, PA, Bloom, GS

J. Cell Biol. 1995
20136777 Regulation of ER-Golgi intermediate compartment tubulation and mobility by COPI coats, motor proteins and microtubules

Tomás, M, Martínez-Alonso, E, Ballesta, J, Martínez-Menárguez, JA

Traffic 2010
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