RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange

Stable Identifier
R-HSA-6811429
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The RIC1:RGP1 complex stimulates nucleotide exchange on trans-Golgi network (TGN)-localized RAB6, activating it (Pusapati et al, 2012; Siniossoglou et al 2001; Siniossoglou et al, 2000). Acitvated RAB6 nucleates a tethering complex at the TGN that is required for fusion of endosome-derived vesicles arriving at the late Golgi (Siniossoglou et al, 2001; Liewen et al, 2005; Perez-Victoria et al, 2008; Perez-Victoria et al, 2009; reviewed in Bonaficino and Hierro, 2011).

Literature References
PubMed ID Title Journal Year
11689439 An effector of Ypt6p binds the SNARE Tlg1p and mediates selective fusion of vesicles with late Golgi membranes

Siniossoglou, S, Pelham, HR

EMBO J. 2001
18367545 Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes

Pérez-Victoria, FJ, Mardones, GA, Bonifacino, JS

Mol. Biol. Cell 2008
23091056 Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase

Pusapati, GV, Luchetti, G, Pfeffer, SR

J. Biol. Chem. 2012
19620288 Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network

Pérez-Victoria, FJ, Bonifacino, JS

Mol. Cell. Biol. 2009
10990452 Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p

Siniossoglou, S, Peak-Chew, SY, Pelham, HR

EMBO J. 2000
21183348 Transport according to GARP: receiving retrograde cargo at the trans-Golgi network

Bonifacino, JS, Hierro, A

Trends Cell Biol. 2011
15878329 Characterization of the human GARP (Golgi associated retrograde protein) complex

Liewen, H, Meinhold-Heerlein, I, Oliveira, V, Schwarzenbacher, R, Luo, G, Wadle, A, Jung, M, Pfreundschuh, M, Stenner-Liewen, F

Exp. Cell Res. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of RAB6:GDP:RIC1:RGP1 [trans-Golgi network membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created