Reactome: A Curated Pathway Database

Intra-Golgi traffic

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

The mammalian Golgi consists of at least three biochemically distinct cisternae, cis-, medial- and trans (reviewed in Szul and Sztul, 2011; Day et al, 2013). The structure and function of the Golgi are tightly interconnected, such that proteins that are required for protein transport through the Golgi are often also required for the organization of the Golgi stacks, and vice versa (reviewed in Liu and Storrie, 2012; Liu and Storrie, 2015; Chia and Gleeson, 2014; Munro, 2011). Newly synthesized proteins from the ER and ERGIC are received at the cis face of the Golgi and flow through to the trans-Golgi before being released to the trans-Golgi network (TGN) for further secretion to the endolysosomal system, plasma membrane or extracellular region. Retrograde flow from the trans- to cis-cisternae moves endocytosed cargo from the extracellular region, the plasma membrane and the endolysosomal system back towards the ER. Intra-Golgi retrograde traffic also returns resident Golgi proteins to their appropriate cisternae, in this way facilitating cisternal remodeling or maturation (reviewed in Boncompain and Perez, 2013; Day et al, 2013). Intra-Golgi traffic in both directions is mediated by COPI carriers, with specificity of transport being determined at least in part by the complement of SNAREs, RABs and tethering proteins involved (reviewed in Szul and Sztul, 2011; Spang 2013; Willet et al, 2013; Chia and Gleeson, 2014).

Literature References
PubMed ID Title Journal Year
23846822 The many routes of Golgi-dependent trafficking Histochem. Cell Biol. 2013
22013193 COPII and COPI traffic at the ER-Golgi interface Physiology (Bethesda) 2011
25343031 Membrane tethering F1000Prime Rep 2014
25708460 How Rab proteins determine Golgi structure Int Rev Cell Mol Biol 2015
23881164 A three-stage model of Golgi structure and function Histochem. Cell Biol. 2013
23732476 Retrograde traffic from the Golgi to the endoplasmic reticulum Cold Spring Harb Perspect Biol 2013
22581368 Are Rab proteins the link between Golgi organization and membrane trafficking? Cell. Mol. Life Sci. 2012
21436057 The golgin coiled-coil proteins of the Golgi apparatus Cold Spring Harb Perspect Biol 2011
23839779 The Golgi puppet master: COG complex at center stage of membrane trafficking interactions Histochem. Cell Biol. 2013
Participant Of
Orthologous Events