MAPKs phosphorylate PP2A

Stable Identifier
R-HSA-6811454
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Activated MAPK1 (ERK2) or MAPK3 (ERK1), recruited to the PP2A complex through IER3 (IEX-1), phosphorylate the regulatory subunit PPP2R5B (B56-beta) or PPP2R5C (B56-gamma) of the PP2A complex on serine residue S368 or S337, respectively. ERK-mediated phosphorylation of the PP2A regulatory subunits causes dissociation of the PP2A complex and prevents PP2A-mediated dephosphorylation of AKT1 (Letourneux et al. 2006, Rocher et al. 2007).

Literature References
PubMed ID Title Journal Year
17200115 Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity

Rocher, G, Letourneux, C, Lenormand, P, Porteu, F

J. Biol. Chem. 2007
16456541 B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK

Letourneux, C, Rocher, G, Porteu, F

EMBO J 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed