Reactome | IER3 recruits MAPKs to PP2A-B56-beta,gamma

IER3 recruits MAPKs to PP2A-B56-beta,gamma

Stable Identifier

R-HSA-6811472

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IEX1 recruits ERKs to PP2A

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IER3 recruits MAPKs to PP2A-B56-beta,gamma

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IER3 (IEX-1) recruits both an activated MAPK (MAPK1 (ERK2) or MAPK3 (ERK1)) and the protein phosphatase 2A (PP2A) complex containing regulatory subunits B56-beta (PPP2R5B) or B56-gamma (PPP2R5C), through an interaction with the B56 subunit, forming a tripartite complex (Letourneux et al. 2006, Rocher et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
16456541	B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK Rocher, G, Porteu, F, Letourneux, C	EMBO J	2006
17200115	Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity Rocher, G, Letourneux, C, Porteu, F, Lenormand, P	J. Biol. Chem.	2007