ING2-bound EP300 acetylates TP53

Stable Identifier
R-HSA-6811508
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The histone acetyltransferase EP300 (p300), recruited to TP53 (p53) by ING2, acetylates TP53 on lysine residue K382, which may contribute to TP53-dependent apoptosis (Padeux et al. 2005). PI5P positively regulates TP53 acetylation (Zou et al. 2007), possibly by increasing the amount of ING2 in the nucleus (Gozani et al. 2003).

Literature References
PubMed ID Title Journal Year
12859901 The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor

Gozani, O, Karuman, P, Jones, DR, Ivanov, D, Cha, J, Lugovskoy, AA, Baird, CL, Zhu, H, Field, SJ, Lessnick, SL, Villasenor, J, Mehrotra, B, Chen, J, Rao, VR, Brugge, JS, Ferguson, CG, Payrastre, B, Myszka, DG, Cantley, LC, Wagner, G, Divecha, N, Prestwich, GD, Yuan, J

Cell 2003
17940011 Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis

Zou, J, Marjanovic, J, Kisseleva, MV, Wilson, M, Majerus, PW

Proc. Natl. Acad. Sci. U.S.A. 2007
16024799 ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation

Pedeux, R, Sengupta, S, Shen, JC, Demidov, ON, Saito, S, Onogi, H, Kumamoto, K, Wincovitch, S, Garfield, SH, McMenamin, M, Nagashima, M, Grossman, SR, Appella, E, Harris, CC

Mol. Cell. Biol. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
peptide-lysine-N-acetyltransferase activity of ING2:EP300:p-S15,S20-TP53 Tetramer [nucleoplasm]
Physical Entity
Activity
This event is regulated
Positively by
Orthologous Events
Authored
Reviewed
Created