ELANE, CTSG or PRTN3 binds bacteria

Stable Identifier
R-HSA-6813659
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Elastase, Proteinase 3, or Cathepsin G binds bacteria
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Polymorphonuclear neutrophils (PMNs) are the most abundant circulating blood leukocytes that are rapidly recruited to sites of infection by host- and/or pathogen-derived components. PMNs provide the first-line defense against infection killing invading pathogens and resolving the inflammation they cause (Kobayashi SD et al. 2005). Activated neutrophils are known to release a variety of molecules, including the neutrophil serine proteases such as neutrophil elastase (ELINE), proteinase 3 (PRTN3) and cathepsin G (CTSG) (Garwicz D et al. 2005). Neutrophil serine proteases contribute to antimicrobial defense by

  • attacking membrane-associated (E. coli) or capsule proteins (S.pneumonia), which leads to loss of membrane integrity (Belaaouaj A et al. 2000; Standish AJ & Weiser JN 2009)
  • processing host immune proteins to generate antimicrobial peptides that can directly kill bacteria (Sorensen OE et al. 2001)
  • targeting and inactivating bacterial virulence factors to attenuate bacteria (Weinrauch Y et al. 2002; Lopez-Boado YS et al. 2004)

Literature References
PubMed ID Title Journal Year
25461571 Neutrophil serine proteases in antibacterial defense

Stapels, DA, Geisbrecht, BV, Rooijakkers, SH

Curr. Opin. Microbiol. 2015
16799473 Neutrophil serine proteases: specific regulators of inflammation

Pham, CT

Nat. Rev. Immunol. 2006
18021746 Neutrophil elastase, proteinase 3 and cathepsin G: physicochemical properties, activity and physiopathological functions

Korkmaz, B, Moreau, T, Gauthier, F

Biochimie 2008
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