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TGM1 [cytosol]
Stable Identifier
R-HSA-6813756
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein-glutamine gamma-glutamyltransferase K ecNumber2.3.2.13/ecNumber, TGM1_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Keratinization (Homo sapiens)
Formation of the cornified envelope (Homo sapiens)
CASP14 cleaves filaggrin (Homo sapiens)
Late cornified envelope [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
TGM1 [cytosol] (Homo sapiens)
Mature cornified envelope [plasma membrane] (Homo sapiens)
No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
TGM1 [cytosol] (Homo sapiens)
CDSN binds the cornified envelope (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
TGM1 [cytosol] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
TGM1 [cytosol] (Homo sapiens)
Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
TGM1 [cytosol] (Homo sapiens)
IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
TGM1 [cytosol] (Homo sapiens)
Lamellar bodies bind the early cornified envelope (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
TGM1 [cytosol] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
TGM1 [cytosol] (Homo sapiens)
Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
TGM1 [cytosol] (Homo sapiens)
Late cornified envelope [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
TGM1 [cytosol] (Homo sapiens)
Plasma membrane resorption (Homo sapiens)
Mature cornified envelope [plasma membrane] (Homo sapiens)
No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
TGM1 [cytosol] (Homo sapiens)
Reinforcement of the Cornified Envelope (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
TGM1 [cytosol] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
TGM1 [cytosol] (Homo sapiens)
TGM1 and involucrin bind the plasma membrane (Homo sapiens)
IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
TGM1 [cytosol] (Homo sapiens)
TGM1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22735 TGM1
Gene Names
TGM1, KTG
Chain
chain:1-817
Reference Genes
BioGPS Gene:7051 TGM1
COSMIC (genes):TGM1 TGM1
CTD Gene:7051 TGM1
dbSNP Gene:7051 TGM1
ENSEMBL:ENSG00000092295 TGM1
ENSEMBL:ENSG00000285348 TGM1
HGNC:11777 TGM1
KEGG Gene (Homo sapiens):7051 TGM1
Monarch:7051 TGM1
NCBI Gene:7051 TGM1
OMIM:190195 TGM1
UCSC:P22735 TGM1
Reference Transcript
RefSeq:NM_000359.2 TGM1
Other Identifiers
0004610154
11741819_a_at
15159
16791219
206008_at
2XZZ
3558044
3558045
3558046
3558047
3558048
3558049
3558050
3558051
3558052
3558054
3558055
3558056
3558058
3558059
3558060
3558061
3558063
3558064
3558065
3558066
3558067
3558070
35947_at
40171
7051
7978222
A_23_P65618
AAA59474
AAA61156
AAA61166
AAA96667
AAH34699
ABF70204
AK301652
AK315843
AL096870
BAA14329
BAA34203
BAF98734
BAG63129
BC034699
CAA41040
CAB015159
CCDS9622
CH471078
D10353
D90287
DQ640500
EAW66047
ENSG00000092295
ENSG00000285348
ENSP00000206765
ENSP00000439446
ENSP00000493587
ENSP00000496483
ENST00000206765
ENST00000206765.10
ENST00000544573
ENST00000544573.5
ENST00000642845
ENST00000646057
EntrezGene:7051
EntrezGene:TGM1
g4507474_3p_at
g4507474_3p_x_at
GE58185
GO:0001533
GO:0003674
GO:0003810
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005737
GO:0005829
GO:0005886
GO:0006464
GO:0007049
GO:0008150
GO:0008219
GO:0008283
GO:0010838
GO:0016020
GO:0016740
GO:0016746
GO:0018149
GO:0030154
GO:0030216
GO:0031224
GO:0031424
GO:0043163
GO:0043167
GO:0043226
GO:0045787
GO:0046872
GO:0048856
GO:0070062
GO:0070268
H0YKI6
H0YLJ6
H0YLT9
H0YMQ8
H0YN27
H0YNM4
HGNC:11777
HPA040171
ILMN_1721134
IPR001102
IPR002931
IPR008958
IPR013783
IPR013808
IPR014756
IPR023608
IPR036238
IPR036985
IPR038765
M55183
M62925
M83227
M83228
M83229
M83230
M86360
M98447
M98447_rna1_at
MIM:190195
MIM:242300
NM_000359
NP_000350
PF00868
PF00927
PF01841
SM00460
TC14000971.hg
TGM1
TGM1-201
TGM1-202
TGM1-211
TGM1-217
UPI000000164D
UPI00017A8155
X57974
Participant Of
input
TGM1 and involucrin bind the plasma membrane
hasComponent
IVL:TGM1:Cell surface [plasma membrane]
Other forms of this molecule
TGM1 [cornified envelope]
TGM1 [plasma membrane]
Inferred To
Ghost homologue of TGM1 [cytosol] (Canis familiaris)
TGM1 [cytosol] (Bos taurus)
TGM1 [cytosol] (Danio rerio)
TGM1 [cytosol] (Drosophila melanogaster)
TGM1 [cytosol] (Mus musculus)
TGM1 [cytosol] (Rattus norvegicus)
TGM1 [cytosol] (Sus scrofa)
TGM1 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_000350.1
OpenTargets
ENSG00000092295
IntEnz
2.3.2.13
ZINC - Substances
TGM1_HUMAN
GeneCards
P22735
ZINC - Biogenic
TGM1_HUMAN
ZINC target
P22735
PRO
P22735
Orphanet
15613
ZINC - Predictions - Purchasable
TGM1_HUMAN
PDB
2XZZ
HMDB Protein
HMDBP00682
Interactors (29)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
IntAct:EBI-12058603 CXCL16
0.488
2
UniProt:Q15040 JOSD1
1
JOSD1 [cytosol]
(R-HSA-5688784)
0.488
2
UniProt:B2RWP4 B2RWP4
0.488
2
UniProt:Q8WVR3 MA11
0.488
2
UniProt:P09211 GSTP1
4
GSTP1 [secretory granule lumen]
(R-HSA-6801488)
GSTP1 [cytosol]
(R-HSA-176051)
GSTP1 [extracellular region]
(R-HSA-6806461)
GSTP1 [ficolin-1-rich granule lumen]
(R-HSA-6801490)
0.488
2
UniProt:Q9BQ66 KR412
0.488
2
UniProt:B2R4U6 B2R4U6
0.488
2
UniProt:P26371 KRTAP5-9
1
KRTAP5-9 [cytosol]
(R-HSA-6810265)
0.488
2
UniProt:P16144-2 ITGB4
0.488
2
UniProt:Q86VE0 MYPOP
0.488
2
UniProt:Q8NE01 CNNM3
0.488
2
UniProt:P13284 IFI30
1
IFI30 [lysosomal lumen]
(R-HSA-1031704)
0.488
2
UniProt:Q9Y5Y2 NUBP2
1
NUBP2 [cytosol]
(R-HSA-2564767)
0.488
2
UniProt:Q14162 SCARF1
2
SCARF1 [plasma membrane]
(R-HSA-2197636)
SCARF1 [endocytic vesicle membrane]
(R-HSA-2239453)
0.488
2
UniProt:Q8IW00 VSTM4
0.488
2
UniProt:P22735 TGM1
3
TGM1 [cornified envelope]
(R-HSA-8847706)
TGM1 [cytosol]
(R-HSA-6813756)
TGM1 [plasma membrane]
(R-HSA-6813757)
0.488
2
UniProt:Q5TA78 LCE4A
1
LCE4A [cytosol]
(R-HSA-6814272)
0.488
2
UniProt:Q5TA76 LCE3A
1
LCE3A [cytosol]
(R-HSA-6814296)
0.488
2
UniProt:Q5T7P3 LCE1B
1
LCE1B [cytosol]
(R-HSA-6814271)
0.488
2
UniProt:Q5T753 LCE1E
1
LCE1E [cytosol]
(R-HSA-6814299)
0.488
2
UniProt:Q9BXJ1-2 C1QTNF1
0.488
2
UniProt:P05187 ALPP
1
ALPP [transport vesicle]
(R-HSA-8847823)
0.488
2
UniProt:Q969P0 IGSF8
0.488
2
UniProt:Q92608 DOCK2
3
DOCK2 [extracellular region]
(R-HSA-6806310)
DOCK2 [specific granule lumen]
(R-HSA-6799558)
DOCK2 [cytosol]
(R-HSA-200938)
0.488
2
UniProt:Q92692-2 NECTIN2
0.488
2
UniProt:Q9UGL9 CRCT1
0.488
2
UniProt:Q6EMK4 VASN
0.488
2
UniProt:Q9BR01 SULT4A1
1
SULT4A1 [cytosol]
(R-HSA-176668)
0.488
2
UniProt:P28330 ACADL
1
ACADL [mitochondrial matrix]
(R-HSA-49489)
0.488
2
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