Reactome | ARFIP2 [cytosol]

ARFIP2 [cytosol]

Stable Identifier

R-HSA-6813848

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Arfaptin-2, ADP-ribosylation factor-interacting protein 2, Partner of RAC1, POR1

Locations in the PathwayBrowser for interactor UniProt:Q13352 ITGB3BP

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External Reference Information

External Reference

UniProt:P53365 ARFIP2

Gene Names

ARFIP2, POR1

Chain

chain:1-341

Reference Genes

BioGPS Gene:23647 ARFIP2

COSMIC (genes):ARFIP2 ARFIP2

CTD Gene:23647 ARFIP2

dbSNP Gene:23647 ARFIP2

ENSEMBL:ENSG00000132254 ARFIP2

HGNC:17160 ARFIP2

Monarch:23647 ARFIP2

NCBI Gene:23647 ARFIP2

OMIM:601638 ARFIP2

UCSC:P53365 ARFIP2

Reference Transcript

Other Identifiers

11739098_x_at

11747685_a_at

11747686_x_at

11748522_a_at

11749818_x_at

11751428_a_at

11756295_x_at

16735102

202109_PM_at

202109_at

23647

3360935

3360936

3360937

3360938

3360940

3360942

3360943

3360944

3360945

3360947

3360948

3360949

3360950

3360951

3360952

3360953

3360954

3360955

3360956

3360957

3360958

3360959

3360960

3360961

3360962

3360963

3360964

3360965

3360966

3360967

3360968

36193_at

42763_at

7946201

A_23_P139228

GE59231

GO:0000423

GO:0001726

GO:0005515

GO:0005525

GO:0005543

GO:0005730

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0005938

GO:0006886

GO:0006914

GO:0007005

GO:0007010

GO:0007264

GO:0008289

GO:0016020

GO:0019904

GO:0030032

GO:0030036

GO:0030742

GO:0031267

GO:0031529

GO:0032588

GO:0034315

GO:0034497

GO:0042802

GO:0043226

GO:0043231

GO:0045296

GO:0070273

GO:0140090

HMNXSV003051331

ILMN_1685430

ILMN_1750690

PH_hs_0004279

TC11001358.hg

U52522_at

g6912601_3p_at

Participates

as a component of

ARFIP2:MyrG-ARL1:GTP [cytosol] (Homo sapiens)

as an input of

ARL1:GTP binds ARFIP2 (Homo sapiens)

Inferred To

Arfip [cytosol] (Drosophila melanogaster)

ARFIP2 [cytosol] (Bos taurus)

ARFIP2 [cytosol] (Caenorhabditis elegans)

ARFIP2 [cytosol] (Canis familiaris)

ARFIP2 [cytosol] (Gallus gallus)

Arfip2 [cytosol] (Mus musculus)

Arfip2 [cytosol] (Rattus norvegicus)

TRIM3 [cytosol] (Sus scrofa)

Cross References

OpenTargets

ENSG00000132254

ENSEMBL

ENST00000445086, ENSP00000391427, ENST00000396777, ENSP00000398375, ENST00000423813, ENSP00000379998, ENSP00000254584, ENST00000254584

HPA

ENSG00000132254-ARFIP2

PRO

P53365

Pharos - Targets

P53365

GlyGen

P53365

HMDB Protein

HMDBP08309

PDB

1I4D, 1I4T, 4DCN, 1I49, 1I4L

Interactors (57)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.911	13
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.83	10
UniProt:P53367 ARFP1			0.75	7
UniProt:P19012 KRT15	1	KRT15 [cytosol] (R-HSA-6809589)	0.718	6
UniProt:Q969L2 MAL2			0.718	6
UniProt:Q9Y371 SHLB1			0.718	6
UniProt:Q13352 ITGB3BP	2	ITGB3BP [nucleoplasm] (R-HSA-606325) ITGB3BP [cytosol] (R-HSA-3006405)	0.666	4
UniProt:Q6RW13 AGTRAP	2	AGTRAP(1-159)-BRAF(288-545) fusion [cytosol] (R-HSA-6802262) AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol] (R-HSA-6802511)	0.666	4
UniProt:P84077 ARF1	2	ARF1 [Golgi membrane] (R-HSA-199971) ARF1 [cytosol] (R-HSA-200826)	0.621	3
UniProt:P62330 ARF6	2	ARF6 [recycling endosome membrane] (R-HSA-2029049) ARF6 [cytosol] (R-HSA-8871121)	0.57	4
UniProt:Q6ZPD8 DGAT2L6	1	DGAT2L6 [endoplasmic reticulum membrane] (R-HSA-8848588)	0.556	3
UniProt:Q8WV15 T255B			0.556	3
UniProt:Q9NQG6 MID51			0.556	3
UniProt:Q9H7Z3 NRDE2			0.556	3
UniProt:P60763 RAC3	3	RAC3 [endoplasmic reticulum membrane] (R-HSA-9714693) RAC3 [plasma membrane] (R-HSA-195338) RAC3 [cytosol] (R-HSA-195335)	0.556	3
UniProt:Q96KN3 PKNX2			0.556	5
UniProt:Q04941 PLP2			0.556	5
UniProt:Q8WYH8 ING5	1	ING5 [nucleoplasm] (R-HSA-3215169)	0.556	3
UniProt:Q96CS2 HAUS1	1	HAUS1 [cytosol] (R-HSA-8855199)	0.556	3
UniProt:Q2KHT4-3 GSG1			0.556	3
UniProt:P37198 NUP62	2	NUP62 [nuclear envelope] (R-HSA-157713) NUP62 [cytosol] (R-HSA-9634226)	0.556	3
UniProt:Q96C03-3 MIEF2			0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P49638 TTPA	1	TTPA [cytosol] (R-HSA-2980979)	0.556	3
UniProt:P08247 SYP	1	SYP [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-5215991)	0.556	3
UniProt:Q6QNY1 BL1S2			0.556	3
UniProt:Q9UFG5 CS025			0.556	3
UniProt:Q9BYV2 TRI54			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q04864-2 REL			0.556	3
UniProt:Q9ULP0-2 NDRG4			0.556	3
UniProt:Q9H0W8 SMG9	1	SMG9 [cytosol] (R-HSA-927812)	0.556	3
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:Q6RW13-2 AGTRAP			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:A1L4K1 FSD2			0.556	3
UniProt:P51861 CDR1			0.556	3
UniProt:O15126 SCAMP1	2	SCAMP1 [plasma membrane] (R-HSA-6806161) SCAMP1 [specific granule membrane] (R-HSA-6806140)	0.556	3
UniProt:Q96MT8 CEP63	1	CEP63 [cytosol] (R-HSA-380267)	0.556	3
UniProt:O75400-2 PRPF40A			0.556	3
UniProt:Q8N9I5 FADS6			0.556	3
UniProt:Q13352-5 ITGB3BP			0.556	3
UniProt:Q00765 REEP5			0.556	3
UniProt:Q8TAC9 SCAM5			0.556	3
UniProt:P15153 RAC2	5	RAC2 [endoplasmic reticulum membrane] (R-HSA-9714482) RAC2 [mitochondrial outer membrane] (R-HSA-9714496) RAC2 [phagocytic vesicle membrane] (R-HSA-5668620) RAC2 [cytosol] (R-HSA-195343) RAC2 [plasma membrane] (R-HSA-195339)	0.556	3
UniProt:Q96AL5 Q96AL5			0.556	3
UniProt:P30405 PPIF			0.556	3
UniProt:Q92730 RND1	1	RND1 [plasma membrane] (R-HSA-396949)	0.556	3
UniProt:Q9NPF5 DMAP1	1	DMAP1 [nucleoplasm] (R-HSA-212166)	0.556	3
UniProt:O43739-2 CYTH3			0.556	3
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.556	3
UniProt:Q96DZ9-2 CMTM5			0.556	3
UniProt:P08779 KRT16	1	KRT16 [cytosol] (R-HSA-201581)	0.556	3
UniProt:O95274 LYPD3	2	cleaved GPI-LYPD3 [extracellular region] (R-HSA-8941013) GPI-LYPD3 [plasma membrane] (R-HSA-8940752)	0.527	2
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.508	2

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